The concentration of fetal red blood cells in first-trimester pregnant women undergoing uterine aspiration is below the calculated threshold for Rh sensitization

Commentary: No-test medication abortion: A sample protocol for increasing access during a pandemic and beyond

“…Recent research has suggested that the risk of Rh sensitization after early abortion is negligible [34][35][36]. Consequently, the National Abortion Federation has concluded that forgoing Rh typing and administration of anti-D immunoglobulin is reasonable for Rh-negative patients having aspiration abortion before 56 days of gestation and may be considered for all patients having MA at less than 70 days [16,37].…”

Medication Abortion Up to 70 Days of Gestation

“…For patients undergoing medication abortion before 10 weeks of gestation, some experts recommend against routine Rh testing and anti-D prophylaxis [6] or advise that forgoing Rh typing and Rh prophylaxis can be considered [61]. Research regarding Rh alloimmunization during early pregnancy continues to evolve [62]. However, based on currently available indirect evidence and the the-oretical risk of Rh D alloimmunization in future pregnancies, ACOG recommends Rh D immune globulin prophylaxis for Rh D-negative patients undergoing medication abortion.…”

Medication Abortion Up to 70 Days of Gestation

“…For patients undergoing medication abortion before 10 weeks of gestation, some experts recommend against routine Rh testing and anti-D prophylaxis (6) or advise that forgoing Rh typing and Rh prophylaxis can be considered (61). Research regarding Rh alloimmunization during early pregnancy continues to evolve (62). However, based on currently available indirect evidence and the theoretical risk of Rh D alloimmunization in future pregnancies, ACOG recommends Rh D immune globulin prophylaxis for Rh D-negative patients undergoing medication abortion.…”