The Concentration of Haemoglobin in the Blood of Young Adult Men and Women: the Effect of Administering Small Doses of Iron for Prolonged Periods

Garry, R. C.; Sloan, A. W.; Weir, J. B. De V.; Wishart, M. M.

doi:10.1079/bjn19540038

Cited by 13 publications

(6 citation statements)

References 44 publications

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“…However, if the same procedure is followed in normal males, then they show an increase in haemoglobin value of approxi mately the same extent as that in women; our experiments have confirmed this. This has also been corroborated in a detailed in vestigation carried out by G arry et al (4). The increase in haemo globin seen following prolonged iron therapy in normal women does not seem to be associated in any way with latent iron deficiency.…”

Section: X I/1959 Haemoglobin and Serum-iron Between Men And Women 203supporting

confidence: 60%

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Causes of the Differences in Haemoglobin and Serum-Iron Between Men and Women

Verloop

Blokhuis

Bos³

1959

Acta Haematol

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Section: X I/1959 Haemoglobin and Serum-iron Between Men And Women 203supporting

confidence: 60%

“…We found an average of 14.0 g. in normal women and 15.6 g. in normal men. This difference is as a rule believed to be endocrinologically determined (2)(3)(4). Wolf-Heidegger (5) however, examining 50 men and 38 women aged 22-27 in Basle, found no difference in erythrocyte counts and only a slight difference in haemoglobin values.…”

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confidence: 99%

Causes of the Differences in Haemoglobin and Serum-Iron Between Men and Women

Verloop

Blokhuis

Bos³

1959

Acta Haematol

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“…10 yielded a mean of 1.35 L min −1 , whereas resulted equal to 4.93 L of blood per L of oxygen, yielding a theoretical of 203 mL L −1 . The slope of such a relationship should be higher in women than in men, due to the lower blood haemoglobin concentration in the former (Garry et al 1954 ). Similarly, it should be increased in acute anaemia and decreased in acute polycythaemia.…”

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confidence: 99%

A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise

et al. 2022

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After a short historical account, and a discussion of Hill and Meyerhof’s theory of the energetics of muscular exercise, we analyse steady-state rest and exercise as the condition wherein coupling of respiration to metabolism is most perfect. The quantitative relationships show that the homeostatic equilibrium, centred around arterial pH of 7.4 and arterial carbon dioxide partial pressure of 40 mmHg, is attained when the ratio of alveolar ventilation to carbon dioxide flow ($${\dot{V}}_{A}/{\dot{V}}_{R}{CO}_{2}$$ V ˙ A / V ˙ R CO 2 ) is − 21.6. Several combinations, exploited during exercise, of pertinent respiratory variables are compatible with this equilibrium, allowing adjustment of oxygen flow to oxygen demand without its alteration. During exercise transients, the balance is broken, but the coupling of respiration to metabolism is preserved when, as during moderate exercise, the respiratory system responds faster than the metabolic pathways. At higher exercise intensities, early blood lactate accumulation suggests that the coupling of respiration to metabolism is transiently broken, to be re-established when, at steady state, blood lactate stabilizes at higher levels than resting. In the severe exercise domain, coupling cannot be re-established, so that anaerobic lactic metabolism also contributes to sustain energy demand, lactate concentration goes up and arterial pH falls continuously. The $${\dot{V}}_{A}/{\dot{V}}_{R}{CO}_{2}$$ V ˙ A / V ˙ R CO 2 decreases below − 21.6, because of ensuing hyperventilation, while lactate keeps being accumulated, so that exercise is rapidly interrupted. The most extreme rupture of the homeostatic equilibrium occurs during breath-holding, because oxygen flow from ambient air to mitochondria is interrupted. No coupling at all is possible between respiration and metabolism in this case.

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“…Presumably if the pregnant woman were short of oxygen with 1 1 g haemoglobin, she would raise it by the same amount, which, in her expanded plasma volume would give a concentration of about 14'5 g/Ioo ml. That she can do so is shown by the fact that, under the stimulus of medicinal iron, she will do it as nonpregnant women and men will, under the same stimulus (see Garry, Sloan, Weir & Wishart, 1954). But, unless prodded, she does not do it.…”

Section: Vol 16mentioning

confidence: 99%

Changing concepts in the nutritional physiology of human pregnancy

Leitch¹

1957

Proc. Nutr. Soc.

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AberdeenshireIt seems to me sometimes that famous dicta of famous men, if repeated often enough, have the unfortunate effect of sterilizing thought instead of enlivening it. For instance the dictum of Claude Bernard that 'La fixit6 du milieu interieur c'est la condition de la vie libre', by focusing the attention of physiologists and biochemists on the static aspect of the composition of bodies, and on physiological devices and dietary requirements to maintain the static equilibrium, may have contributed to a somewhat rigid attitude of mind. So many are still reluctant to recognize that the equilibrium of the milieu intirieur may be set at different levels in the same organism and they continue to regard as pathological much of the amazing range of variation that is, in fact, compatible with healthy life. Pregnancy offers an outstanding example of this. Twenty years agoWhen Garry & Stiven (1935-6) wrote the first review of metabolism in pregnancy for Nutrition Abstracts and Reviews, 20 years ago, it was customary to assess the normality of the pregnant woman, for instance in respect of composition of the blood and basal metabolic rate, by comparison with accepted standards for non-pregnant women, and inquiries about diet were concerned with how much extra protein or calcium or iron the pregnant woman might require to supply the foetus and additional maternal tissues. And this attitude persisted although it had already been demonstrated that, on any ordinary diet in this country or America, the pregnant woman stored nitrogen and structural minerals in amounts far in excess of those in foetus and maternal accessory tissues. 'The diagnosis of anaemia' the review says 'will depend on the "normal" standard adopted for non-pregnant women, which is difficult to define, since the range of variation is wide'. And, of course, a diagnosis of anaemia meant the prescription of iron.On the other hand, we have this pearl of wisdom following a review of studies of birth weight: 'Hence, it is possible that, under any but extreme conditions, the birth weight of the child depends less on the food intake of the mother than on its https://www.cambridge.org/core/terms. https://doi

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The Concentration of Haemoglobin in the Blood of Young Adult Men and Women: the Effect of Administering Small Doses of Iron for Prolonged Periods

Cited by 13 publications

References 44 publications

Causes of the Differences in Haemoglobin and Serum-Iron Between Men and Women

Causes of the Differences in Haemoglobin and Serum-Iron Between Men and Women

A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise

Changing concepts in the nutritional physiology of human pregnancy

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