The concentration of insulin-like growth factor-1 in pregnancies complicated by pregnancy-induced hypertension and/or intrauterine hypotrophy

Gazy, Patrycja; Marciniak, Sylwia; Sławska, Helena; Olejek, Anita; Mazur, Bogdan

doi:10.5603/gp.2020.0087

Cited by 1 publication

(1 citation statement)

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“…Previous reports of cord blood IGF-1 levels are strongly associated with the birth weight, the leptin level, the fat mass, and the body fat percentage, which indicate that IGF-1 is an important factor in the fetal fat accumulation in the uterus [ 27 ]. Another previous study reports that newborns who are born to mothers with pregnancy hypertension had lower cord blood IGF-1 levels compared with those born to mothers without pregnancy hypertension, and the SGA newborns showed low cord blood IGF-1 levels [ 28 ]. Consistent with the results, in our present study, the cord blood IGF-1 levels were lower in the SGA newborns compared to those of the non-SGA newborns in all four GA groups.…”

Section: Discussionmentioning

confidence: 99%

Percentile-Based Reference Values of Umbilical Cord Blood Insulin-like Growth Factor 1 in Japanese Newborns

Nagano

Katayama

Hara

et al. 2022

JCM

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We aimed to create percentile-based reference values of the umbilical cord blood insulin-like growth factor-1 (IGF-1) levels in Japanese newborns, as these values have not yet been established. A total of 259 newborns were classified into four gestational-age-at-birth (GA) groups: extremely preterm (<28 weeks); early preterm (28–33 weeks); late preterm (34–36 weeks); and term (≥37 weeks). They were further subclassified as small-for-gestational-age (SGA) or non-SGA. The 10th, 25th, 50th, 75th, and 90th percentiles of the umbilical cord blood IGF-1 levels were calculated and compared between the groups by using reference values of 9, 18, 33, 52, and 71 ng/mL, respectively. In the extremely preterm group, the IGF-1 levels were significantly lower than those in the early preterm, late preterm, and term groups (13.5, 24.0, 44.5, and 47.5 ng/mL, respectively; p < 0.001). The umbilical cord blood IGF-1 levels in the SGA newborns were significantly lower than those in the non-SGA newborns in all subgroups. In multivariate analyses, the GA and birth weight standard deviation scores were independent determinant factors for the umbilical cord blood IGF-1 levels. Thus, we established percentile-based reference values of umbilical cord blood IGF-1 in Japanese newborns; these reference values can be applied on the basis of the extent of prematurity and the SGA status.

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Section: Discussionmentioning

confidence: 99%