The Concentration of Omega-3 Fatty Acids in Human Milk Is Related to Their Habitual but Not Current Intake

Bzikowska‐Jura, Agnieszka; Czerwonogrodzka–Senczyna, Aneta; Jasińska-Melon, Edyta; Mojska, Hanna; Olędzka, Gabriela; Wesołowska, Aleksandra; Szostak-Węgierek, Dorota

doi:10.3390/nu11071585

Cited by 42 publications

(51 citation statements)

References 63 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As result, it can be concluded that BM metabolites vary during the first month of lactation and the highest variability has been shown in pre-term samples [20]. In a recent study, Bzikowska-Jura and co-workers [64] investigated FAs levels in BM, determining omega-3 FA content in relation to maternal current dietary intake. N=32 samples from n=32 women during the first month of lactation were analyzed with GC-MS.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Clinical insights gained through metabolomic analysis of human breast milk

Bardanzellu

Peila

Fanos

et al. 2019

Expert Review of Proteomics

View full text Add to dashboard Cite

Introduction: Among the OMICS technologies, that have emerged in recent years, metabolomics has allowed relevant step forwards in clinical research. Several improvements in disease diagnosis and clinical management have been permitted, even in neonatology. Among potentially evaluable biofluids, breast milk (BM) results are highly interesting, representing a fluid of conjunction between mothers newborns, describing their interaction. Areas covered: in this review, updating a previous review article, we discuss research article and reviews on BM metabolomics and found in MEDLINE using metabolomics, breast milk, neonatal nutrition, breastfeeding, human milk composition and preterm neonates as keywords. Expert opinion: Our research group has a profound interest in metabolomics research. In 2012, we published the first metabolomic analysis on BM samples, reporting interesting data on its composition and relevant differences with formula milk (FM), useful to improve FM composition. As confirmed by successive studies, such technology can detect the specific BM composition and its dependence on several variables, including lactation stage, gestational age, maternal or environmental conditions. Moreover, since BM contaminants or drug levels can be detected, metabolomics also results useful to determine BM safety. These are only few practical applications of BM analysis, which will be reviewed in this paper.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

“…As result, current dietary intake of omega-3 FAs was not significantly correlated with BM content, while their habitual intake could influence BM levels. Nutritional habits in the three months prior delivery mainly affect BM [64].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Clinical insights gained through metabolomic analysis of human breast milk

Bardanzellu

Peila

Fanos

et al. 2019

Expert Review of Proteomics

View full text Add to dashboard Cite

show abstract

“…The impact of physiological factors, e.g., sequential stages of lactation [ 8 , 9 ], pre-/post-feed [ 10 ] and daytime [ 11 ] is the best investigated. Changes in maternal diet [ 12 , 13 , 14 ] and nutritional status [ 15 , 16 ] also significantly influence HM composition, mainly within the lipid fraction. Likewise, the concentrations of non-nutritive milk components (e.g., hormones, steroids, growth and satiety factors) are affected by maternal factors [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Infant and Maternal Factors on Energy and Macronutrient Composition of Human Milk

et al. 2020

Self Cite

View full text Add to dashboard Cite

The present study investigates the influence of selected infant and maternal factors on the energy and macronutrient composition of mature human milk (HM). The study enrolled 77 mothers at 4–8 weeks postpartum. Each mother provided 1 sample of HM. Each extracted HM sample was formed by mixing four subsamples of HM, each of which were obtained in one predefined 6-h periods of the day. Among maternal factors, the analysis included: anthropometric data before and after pregnancy; weight gain in pregnancy; body composition, assessed using the Maltron BioScan 920-II to analyze bioimpedance; and dietary intake, assessed with three-day dietary records. Among the neonatal factors, birth weight and length, number of daily feedings and type of delivery were included. The composition of HM, including energy content, protein, fat and carbohydrate concentrations, was analyzed using the Miris human milk analyzer. Pearson’s and Spearman’s correlation coefficients and multivariable logistic regression models were used to analyze the association between the selected maternal and infant factors and HM milk composition. It was found that total protein content of HM was correlated with pre-pregnancy BMI (Spearman rho = 0.238; p = 0.037), current lean body mass (Spearman rho = −0.293, p = 0.01) and total water content (Spearman rho = −0.315, p = 0.005). Carbohydrates were the only macronutrients whose composition was significantly affected by the infant factors. It was reported that higher carbohydrate content was associated with male sex (OR = 4.52, p = 0.049). Our results show that maternal and infant factors, especially maternal pre-pregnancy and current nutritional status and infant sex, interact and affect HM composition, suggesting that macronutrient and energy content in HM may be determined in pregnancy and may have unique compositional profile for every mother–infant dyad.

show abstract

“…Despite the similarities in MFGM proteome, the composition of bovine milk differs from human milk. An example is the content of essential unsaturated fatty acids, which is higher in human milk than in bovine milk because of the high rate of biohydrogenation processes of dietary unsaturated fatty acids in the rumen-α-linolenic acid shows a lower difference (0.5-2% and 1-2% of total milk FAs for bovine and human milk fat, respectively) than linoleic acid (1-3% and 8-18% of total milk FAs for bovine and human milk fat, respectively) [25,29,82,83]. In addition to nutrients, human breast milk also contains several bioactive compounds (Igs, enzymes, hormones) and live cells (e.g., leucocytes) that cannot be easily added to IFs [79,84].…”

Section: Itemmentioning

confidence: 99%

Comparative Proteomics of Milk Fat Globule Membrane (MFGM) Proteome across Species and Lactation Stages and the Potentials of MFGM Fractions in Infant Formula Preparation

Manoni

Lorenzo

Ottoboni

et al. 2020

Foods

View full text Add to dashboard Cite

Milk is a lipid-in-water emulsion with a primary role in the nutrition of newborns. Milk fat globules (MFGs) are a mixture of proteins and lipids with nutraceutical properties related to the milk fat globule membrane (MFGM), which protects them, thus preventing their coalescence. Human and bovine MFGM proteomes have been extensively characterized in terms of their formation, maturation, and composition. Here, we review the most recent comparative proteomic analyses of MFGM proteome, above all from humans and bovines, but also from other species. The major MFGM proteins are found in all the MFGM proteomes of the different species, although there are variations in protein expression levels and molecular functions across species and lactation stages. Given the similarities between the human and bovine MFGM and the bioactive properties of MFGM components, several attempts have been made to supplement infant formulas (IFs), mainly with polar lipid fractions of bovine MFGM and to a lesser extent with protein fractions. The aim is thus to narrow the gap between human breast milk and cow-based IFs. Despite the few attempts made to date, supplementation with MFGM proteins seems promising as MFGM lipid supplementation. A deeper understanding of MFGM proteomes should lead to better results.

show abstract

The Concentration of Omega-3 Fatty Acids in Human Milk Is Related to Their Habitual but Not Current Intake

Cited by 42 publications

References 63 publications

Clinical insights gained through metabolomic analysis of human breast milk

Clinical insights gained through metabolomic analysis of human breast milk

Impact of Infant and Maternal Factors on Energy and Macronutrient Composition of Human Milk

Comparative Proteomics of Milk Fat Globule Membrane (MFGM) Proteome across Species and Lactation Stages and the Potentials of MFGM Fractions in Infant Formula Preparation

Contact Info

Product

Resources

About