The concentration of pyroglutamic acid (2-pyrrolidone-5-carboxylic acid) in normal and psoriatic epidermis, determined on a microgram scale by gas chromatography

Marstein, Sverre; Jellum, Egil; Eldjarn, L.

doi:10.1016/0009-8981(73)90237-4

Cited by 46 publications

(28 citation statements)

References 11 publications

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“…The competitive inhibition of KLK7 by pyroglutamic acid with K i = 33 mM identifies this amino acid as a candidate in controlling KLK7 activity in skin where pyroglutamic acid concentration is 1.6% (124 mM) and functions as a natural moisturizer [74]. Pyroglutamic acid is also named 5-oxoproline which emphasizes its difference from proline (Scheme 1) that surprisingly increased KLK7 activity (data not shown).…”

Section: Discussionmentioning

confidence: 81%

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Oliveira

Bertolin

Andrade

et al. 2015

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Section: Discussionmentioning

confidence: 81%

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Oliveira

Bertolin

Andrade

et al. 2015

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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“…In the absence of NMF, the SC is dry, does not desquamate properly and has poor waterholding capacity. Patients with ichthyosis vulgaris and psoriasis lack NMF and have severe scaling, flaking and cracking [19,20]. Rawlings et al have reported decreased levels of NMF in the SC of aged skin and attribute the decrease to ultraviolet damage [18].…”

Section: Discussionmentioning

confidence: 99%

Effect of semipermeable membranes on skin barrier repair following tape stripping

Visscher¹,

Hoath²,

Conroy

et al. 2001

Arch Dermatol Res

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Reports in the literature suggest that the permeability of a wound dressing to water transport is an important variable in the healing of superficial wounds. Factors that influence skin hydration during barrier repair, therefore, are important in the optimization of wound treatments. In this study, the effects of semipermeable films on human skin following a standardized wound (tape stripping) were evaluated using measurements of transepidermal water loss (TEWL), skin hydration, rate of moisture accumulation, and erythema. Wounds treated with semipermeable films underwent more rapid barrier recovery than either unoccluded wounds or wounds under complete occlusion. Barrier films that produced intermediate levels of skin hydration during recovery produced the highest barrier repair rates. The results support the hypothesis; that semipermeable wound dressings augment barrier repair and skin quality by providing an optimized water vapor gradient during the wound healing process. The choice of wound dressing is discussed within the larger context of the design of vapor-permeable fabrics (smart materials) and the new fields of corneotherapy and comfort science.

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“…As these cells differentiate into corneocytes in the SC, profilaggrin undergoes proteolysis to filaggrin. The latter is ultimately degraded into free AAs, some of which are further transformed into pyrrolidone carboxylic acid, urocanic acid, citrulline and urea (16,17).…”

Section: Introductionmentioning

confidence: 99%

Reverse Iontophoresis of Amino Acids: Identification and Separation of Stratum Corneum and Subdermal Sources In Vitro

et al. 2009

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The concentration of pyroglutamic acid (2-pyrrolidone-5-carboxylic acid) in normal and psoriatic epidermis, determined on a microgram scale by gas chromatography

Cited by 46 publications

References 11 publications

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Effect of semipermeable membranes on skin barrier repair following tape stripping

Reverse Iontophoresis of Amino Acids: Identification and Separation of Stratum Corneum and Subdermal Sources In Vitro

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