The concentration of uric acid in patients with metabolic syndrome and cardiovascular diseases

Kowalski, Jan; Krzemińska, Anna; Banach, Maciej; Pawlicki, Lucjan; Śliwczyńska-Rodziewicz, Dorota; Barylski, Marcin

doi:10.2478/s11536-009-0026-5

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Взаимосвязь между ГУ, подагрой и компонентами МС, включая нарушения углеводного обмена, показана во многих, в том числе популяционных, исследованиях [18][19][20]. Накапливаются данные о том, что наличие подагры повышает риск развития МС и непосредственно СД2.…”

Section: Discussionunclassified

Contributing factors of diabetes mellitus among patients with gout (results of the long-term prospective study)

Zhelyabina¹,

Елисеев²,

Глухова³

et al. 2022

Naučno-praktičeskaâ revmatologiâ

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It is assumed that the risk of developing type 2 diabetes mellitus (T2DM) in patients with gout is influenced by both generally accepted risk factors and factors related to gout.Objective. To evaluate the impact of various risk factors for T2DM in patients with gout.Material and methods. 444 patients (49 women, 395 men) ≥18 years old with gout and without DM were included. Duration of observation was 5.66 [2.69; 7.64] g. To identify factors associated with the risk of developing T2DM, multivariate logistic regression was used, which included: sex; T2DM in relatives; insufficient physical activity; unbalanced diet; age ≥45 years; ≥4 attacks per year; presence of tophi; BMI≥30 kg/m2 ; allopurinol, febuxostat, glucocorticoids, diuretics, metformin, colchicine; GFR<60 ml/min/1.73 m2 ; serum uric acid level (sUA) ≥420 μmol/l and ≥480 μmol/l. Results. T2DM developed in 108 (24.3%) patients. According to the multivariate model, the presence of ≥4 attacks of arthritis per year increased the risk of T2DM (OR=5.23; 95% CI: 2.98–9.19; p=0.0001); presence of tophi (OR=2.61; 95% CI: 1.50–4.54; p=0.001); sUA≥480 μmol/l (OR=2.26; 95% CI: 1.02–5.00; p=0.144), diuretics (OR=2.35; 95% CI: 1.19–4.64; p=0.014). Febuxostat (OR=0.31; 95% CI: 0.11–0.84; p=0.022) and metformin (OR=0.49; 95% CI: 0.21–1.16; p=0.107) reduced the risk of developing T2DM. Conclusion. Risk of T2DM in patients with gout is associated with high incidence of arthritis attacks, MK≥480 μmol/l, hypertension, diuretic use, and febuxostat and metformin reduces risk. Key words: gout, type 2 diabetes mellitus, uric acid>˂ 60 ml/min/1.73 m2 ; serum uric acid level (sUA) ≥420 μmol/l and ≥480 μmol/l.Results. T2DM developed in 108 (24.3%) patients. According to the multivariate model, the presence of ≥4 attacks of arthritis per year increased the risk of T2DM (OR=5.23; 95% CI: 2.98–9.19; p=0.0001); presence of tophi (OR=2.61; 95% CI: 1.50–4.54; p=0.001); sUA≥480 μmol/l (OR=2.26; 95% CI: 1.02–5.00; p=0.144), diuretics (OR=2.35; 95% CI: 1.19–4.64; p=0.014). Febuxostat (OR=0.31; 95% CI: 0.11–0.84; p=0.022) and metformin (OR=0.49; 95% CI: 0.21–1.16; p=0.107) reduced the risk of developing T2DM.Conclusion. Risk of T2DM in patients with gout is associated with high incidence of arthritis attacks, MK≥480 μmol/l, hypertension, diuretic use, and febuxostat and metformin reduces risk.

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Section: Discussionunclassified

Contributing factors of diabetes mellitus among patients with gout (results of the long-term prospective study)

Zhelyabina¹,

Елисеев²,

Глухова³

et al. 2022

Naučno-praktičeskaâ revmatologiâ

View full text Add to dashboard Cite

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“…Many studies have shown a relationship between hyperuricemia and cardiovascular disease (Kostka-Jeziorny et al, 2019;Kowalski et al, 2009;Zhang et al, 2019). Several studies on hyperuricemia patients have reported SUA concentration as a marker of pathophysiology processes that correlated with the development of cardiovascular disease (Zhang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum uric acid concentration and cardiovascular risk factors in normotensivepostmenopausal women with dyslipidemia

Dobrzyńska¹,

Przysławski²

2020

Acta Sci Pol Technol Aliment

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Background. According to the latest recommendation for patients with hyperuricemia and high cardiovascular risk, the serum uric acid (SUA) concentration should be lower than 5 mg/dL (<298 μmol/L). Additionally, studies have shown that SUA concentration in participants with hyperuricemia correlates with some dietary factors. The aim of this study was to assess the relationship between SUA concentration and some cardiovascular risk factors. Material and methods. Fifty-six postmenopausal women with dyslipidemia and without hypertension were assigned to 2 groups based on SUA concentration. The first group consisted of women with a SUA concentration ≥5 mg/dL and without gout, and the second group comprised women with a SUA concentration <5 mg/dL. Anthropometric parameters, nutrition, structure of consumption, dietary potential renal acid load (PRAL), lipid profile parameters and blood pressure were evaluated. Results. Postmenopausal women with a SUA ≥5 mg/dL had statistically significant higher values of serum triglyceride (TG) concentration, waist-to-hip ratio (WHR) and diastolic blood pressure than women with a SUA concentration <5 mg/dL. Analysis of nutrition showed statistically significant differences between the groups in the intake of starch, saturated and polyunsaturated fatty acids, cholesterol and vitamin E. Additionally, we observed a correlation between PRAL value and SUA. The structure of consumption between the groups was varied. Conclusion. SUA concentration ≥5 mg/dL may increase the cardiovascular risk. The association observed between PRAL and SUA can be used to evaluate diet.

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Contributing Factors of Diabetes Mellitus among Patients with Gout (Results of the Long-Term Prospective Study)

Zheliabina,

Eliseev,

Glukhova

et al. 2023

Dokl Biochem Biophys

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It is assumed that the risk of developing type 2 diabetes mellitus (T2DM) in patients with gout is influenced by both generally accepted risk factors and factors related to gout. The aim of the study was to evaluate the impact of various risk factors for T2DM in patients with gout. A total of 444 patients (49 women, 395 men) ≥18 years old with gout and without DM were included. The duration of observation was 5.66 [2.69; 7.64] years. To identify the factors associated with the risk of developing T2DM, multivariate logistic regression was used, which included sex; T2DM in relatives; insufficient physical activity; unbalanced diet; age ≥ 45 years; ≥4 attacks per year; presence of tophi; BMI ≥30 kg/m2; allopurinol, febuxostat, glucocorticoids, diuretics, metformin, colchicine; GFR < 60 mL/min/1.73 m2; serum uric acid level (sUA) ≥ 420 µmol/L and ≥ 480 µmol/L. T2DM developed in 108 (24.3%) patients. According to the multivariate model, the presence of ≥4 attacks of arthritis per year increased the risk of T2DM (OR = 5.23; 95% CI: 2.98–9.19; p = 0.0001); presence of tophi (OR = 2.61; 95% CI: 1.50–4.54; p = 0.001); sUA ≥ 480 µmol/L (OR = 2.26; 95% CI: 1.02–5.00; p = 0.144); diuretics (OR = 2.35; 95% CI: 1.19–4.64; p = 0.014). Febuxostat (OR = 0.31; 95% CI: 0.11–0.84; p = 0.022) and metformin (OR = 0.49; 95% CI: 0.21–1.16; p = 0.107) reduced the risk of developing T2DM. Risk of T2DM in patients with gout is associated with high incidence of arthritis attacks, MK ≥ 480 μmol/L, hypertension, diuretic use, and febuxostat and metformin reduces risk.

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The concentration of uric acid in patients with metabolic syndrome and cardiovascular diseases

Cited by 4 publications

References 38 publications

Contributing factors of diabetes mellitus among patients with gout (results of the long-term prospective study)

Contributing factors of diabetes mellitus among patients with gout (results of the long-term prospective study)

The relationship between serum uric acid concentration and cardiovascular risk factors in normotensivepostmenopausal women with dyslipidemia

Contributing Factors of Diabetes Mellitus among Patients with Gout (Results of the Long-Term Prospective Study)

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