The concentrations of major and trace elements in rat kidney: Aging effects and mutual relationships

Shimamura, Tadashi; Iijima, Satoe; Hirayama, Mitsuhiro; Iwashita, Masato; Akiyama, Shigeru; Takaku, Yuichi; Yumoto, Sakae

doi:10.1016/j.jtemb.2012.05.005

Cited by 17 publications

(13 citation statements)

References 37 publications

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“…For example, Fe has been measured to be 23.66 mg kg –1 and 267 mg kg –1 . A similar variation in concentration has been observed for Cu (6.33–160 mg kg –1 ) and Mg (196–636 mg kg –1 ) . Even with this large variation, our data falls within the reported ranges for both the essential and trace minerals.…”

Section: Discussionsupporting

confidence: 89%

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The Distribution of Essential, Trace, and Nonessential Minerals in Weanling Male Rats Fed Sheep or Cow Milk

Burrow

Young

McConnell

et al. 2018

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 89%

“…Literature reports show an extremely wide range of mineral concentrations in the kidney. For example, Fe has been measured to be 23.66 mg kg –1 and 267 mg kg –1 . A similar variation in concentration has been observed for Cu (6.33–160 mg kg –1 ) and Mg (196–636 mg kg –1 ) .…”

Section: Discussionsupporting

confidence: 66%

The Distribution of Essential, Trace, and Nonessential Minerals in Weanling Male Rats Fed Sheep or Cow Milk

Burrow

Young

McConnell

et al. 2018

Molecular Nutrition Food Res

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“…The essential and trace mineral concentrations in the organs and serum observed in this study were within the reported range for growing rats [48,49]. Most of the differences observed with respect to the essential and trace mineral concentrations occurred in spleen and liver (Table 4), which relates to the role these organs have in mineral metabolism, regulation, and storage [50].…”

Section: Controlsupporting

confidence: 79%

“…Shimamura, et al [48] showed that 17-week-old female Wistar rats had liver As concentrations of 570 ± 180 µg/kg. For kidney, Shimamura, et al [49] showed that 17 week old female Wistar rats had an average As concentration of 810 ± 200 µg/kg. When our data are compared with this published literature, it indicates that although As accumulation did occur, the accumulation was not of concern for animal health due to the low concentrations observed.…”

Section: Non-essential Minerals In Soft Organs and Serummentioning

confidence: 99%

The Effect of Sheep and Cow Milk Supplementation of a Low Calcium Diet on the Distribution of Macro and Trace Minerals in the Organs of Weanling Rats

et al. 2020

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The aim of this study was to investigate the effect of either sheep or cow milk supplementation to a low calcium and phosphorus diet on growth and organ mineral distribution in weanling rats. Rats were fed diets consisting of either a control chow, a 50% reduced calcium and phosphorous chow (low Ca/P), low Ca/P and sheep milk, or low Ca/P and cow milk diet for 28 days. Food intake of the rats, the growth rate of the rats, and the concentrations of minerals in the soft organs and serum were determined. Rats fed the low Ca/P diet alone had lower weight gain than rats consuming either of the milk-supplemented diets (p < 0.05). Both sheep milk and cow milk supplementation overcame the effects of consuming a diet restricted in calcium and phosphorus but the sheep milk was effective at a significantly lower level of milk intake (p < 0.05). Significant differences (p < 0.05) in essential and trace mineral concentrations due to milk type were observed in the kidney, spleen, and liver. For non-essential minerals, significant differences (p < 0.05), related to diet, were observed in all organs for arsenic, cesium, rubidium, and strontium concentrations.

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“…kidney, along with the liver, is rich in anti-oxidant trace elements [11][12][13] . However, under some circumstances where ROS generation exceeds the reducing capacity of the resident antioxidant defences, as may often occur in the ischaemia-susceptible kidney, then structural and functional impairment including apoptosis and necrosis can occur 14 .…”

mentioning

confidence: 99%

Renal accumulation of prooxidant mineral elements and CKD in domestic cats

Alborough

Grau‐Roma

Brot

et al. 2020

Sci Rep

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felids have a high incidence of chronic kidney disease (cKD), for which the most common renal lesion is chronic interstitial nephritis (cin). cin can be induced by tissue oxidative stress, which is determined by the cellular balance of pro-and anti-oxidant metabolites. Fish-flavoured foods are more often fed to cats than dogs, and such foods tend to have higher arsenic content. Arsenic is a pro-oxidant metallic element. We propose that renal accumulation of pro-oxidant elements such as arsenic and depletion of anti-oxidant elements such as zinc, underpin the high incidence of cin in domestic cats. total arsenic and other redox-reactive metal elements were measured in kidneys (after acid-digestion) and urine (both by inductively-coupled plasma-mass spectrometry) of domestic cats (kidneys, n = 56; urine, n = 21), domestic dogs (kidneys, n = 54; urine, n = 28) and non-domesticated Scottish Wildcats (kidneys, n = 17). Renal lesions were graded by severity of CIN. In our randomly sampled population, CIN was more prevalent in domestic cat versus domestic dog (51%, n = 32 of 62 cats; 15%, 11 of 70 dogs were positive for cin, respectively). cin was absent from all Scottish wildcats. tissue and urinary (corrected for creatinine) arsenic content was higher in domestic cats, relative to domestic dogs and wildcats. Urine arsenic was higher in domestic cats and dogs with cin. Arsenobetaine, an organic and relatively harmless species of arsenic, was the primary form of arsenic found in pet foods. in summary, the kidneys of domestic cats appear to have greater levels of pro-oxidant trace elements, as compared to dogs and wildcats. Since there was no difference in renal arsenic levels in cats with or without CIN, renal arsenic accumulation does not appear a primary driver of excess CIN in cats. Given clear differences in renal handling of pro vs. anti-oxidant minerals between cats and dogs, further in vivo balance studies are warranted. These may then inform species-specific guidelines for trace element incorporation into commercial diets.Chronic kidney disease (CKD) is commonly diagnosed in domestic cats, with a reported prevalence of 1-3% in the overall domestic cat population 1 . One study reported prevalence as high as 50% and 80% in cats of all ages and aged over 15 years, respectively 2 . This contrasts to a reported prevalence of <1% in all dogs 3 and only 10% in dogs over 15 years of age 1 . CKD is defined as the irreversible loss of structure and/or function of one or both kidneys that results from a progressive process occurring over a period of 3 months or more 1 . CKD has various aetiologies, but mononuclear cell tubulointerstitial nephritis -inflammation of the interstitial cells surrounding tubules, predominantly proximal -together with interstitial fibrosis and tubular atrophy is the common histopathological finding in most cases of CKD in cats 4,5 and dogs 6 .Renal tubular epithelial cells are highly metabolically active with high mitochondrial density in order to support oxidative phosphorylation and energy-depe...

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The concentrations of major and trace elements in rat kidney: Aging effects and mutual relationships

Cited by 17 publications

References 37 publications

The Distribution of Essential, Trace, and Nonessential Minerals in Weanling Male Rats Fed Sheep or Cow Milk

The Distribution of Essential, Trace, and Nonessential Minerals in Weanling Male Rats Fed Sheep or Cow Milk

The Effect of Sheep and Cow Milk Supplementation of a Low Calcium Diet on the Distribution of Macro and Trace Minerals in the Organs of Weanling Rats

Renal accumulation of prooxidant mineral elements and CKD in domestic cats

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