The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine

Im, Gun‐Il

doi:10.1007/s13770-022-00436-6

Cited by 24 publications

(18 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that the cartilage and subchondral bone of the site of tissue damage in these cases might be the result of some pathological conditions such as development of early osteoarthritis before implantation of the TEC. 14,16 In addition, since the patients in cases 3 and 5 underwent the TEC implantation surgeries 6 months or more after knee chondral injury (Table 1), such delayed surgery (a more chronic condition) might affect clinical outcomes and the quality of the repair cartilage, as reported in the previous studies. 9,29 In any case, of note is that the slight deterioration of repair tissue did not immediately affect the scores of patientreported outcome measures, and thus longer follow-up will be required to draw firmer conclusions.…”

Section: Discussionmentioning

confidence: 84%

Five-Year Outcomes After Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stromal Cells for Repair of Knee Chondral Lesions

Shimomura

Ando

Hart

et al. 2023

Orthopaedic Journal of Sports Medicine

View full text Add to dashboard Cite

Background: In an earlier study, a scaffold-free tissue-engineered construct (TEC) derived from autologous synovial membrane mesenchymal stromal cells (MSCs) was developed and demonstrated to be safe and effective for cartilage repair at 2 years postoperatively. Purpose: To investigate clinical outcomes and magnetic resonance imaging (MRI) findings at 5 years after implantation. Study Design: Case series; Level of evidence, 4. Methods: This was an observational first-in-human study limited to 5 patients (age, 28-46 years) with symptomatic knee chondral lesions (size, 1.5-3.0 cm2) on the medial femoral condyle, lateral femoral condyle, or femoral groove. Synovial MSCs were isolated from arthroscopic biopsy specimens and cultured to develop a TEC that matched the lesion size. The TECs were then implanted into chondral defects without fixation and assessed at up to 5 years postoperatively. The patients were clinically evaluated using the visual analog scale for pain, Lysholm score, Tegner score, and Knee injury and Osteoarthritis Outcome Score. An MRI scan evaluation was also performed for morphologic and compositional quality of the repair tissue at both 2 and 5 years of follow-up. Results: All clinical scores were significantly improved from the preoperative evaluation to the 2- and 5-year follow-ups and the results were stable over time. The MRI scan evaluation showed cartilage defects filled with newly generated tissues with good tissue integration to adjacent host cartilage over time. The cartilage thickness and surface smoothness of the repair cartilage were maintained up to 5 years postoperatively. The MOCART (magnetic resonance observation of cartilage repair tissue) 2.0 Knee Scores remained high at 5 years, although the total points decreased slightly. Conclusion: The results highlight the efficacy and feasibility of autologous scaffold-free TEC derived from synovial MSCs for regenerative cartilage repair via a sutureless and simple implantation procedure, showing good clinical outcomes and MRI findings with stable results at midterm follow-up. Further follow-up will be needed to assess the long-term quality of the repair tissue.

show abstract

Section: Discussionmentioning

confidence: 84%

Five-Year Outcomes After Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stromal Cells for Repair of Knee Chondral Lesions

Shimomura

Ando

Hart

et al. 2023

Orthopaedic Journal of Sports Medicine

View full text Add to dashboard Cite

show abstract

“…In the current study, we focused on intact cartilage, as potential OA therapeutics are most likely to be successful in halting or reversing OA progression at an early stage of the disease, before substantial cartilage degradation has occurred. 71 Of course, early intervention would require further advances in our ability to diagnose early-stage OA. A recent study investigated the effect of partial digestion of bovine cartilage explants with collagenase type II (as a model of OA) on nanoparticle uptake.…”

Section: Resultsmentioning

confidence: 99%

Designing polymers for cartilage uptake: effects of architecture and molar mass

Gong,

Nhan,

St-Pierre

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…The various phenotypes proposed for OA include chronic pain phenotype, inflammatory phenotype, metabolic syndrome phenotype, mechanical overload phenotype, minimal joint disease phenotype, senescent phenotype, endocrine phenotype, and sarcopenic phenotype as shown in Figure 1 [ 6 , 8 , 9 ]. Prospective studies are needed to validate the efficacy of these phenotypic subtype-based management methods to surpass or prevent symptoms at an early stage before progressive and irreversible changes occur[ 10 ].…”

Section: Oa Phenotypesmentioning

confidence: 99%

Osteoarthritis, an old wine in a new bottle!

Muthu¹

2023

World J Orthop

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common form of arthritis that has a major impact on patient morbidity and health care services. Despite its prevalence and impact, we do not have any effective management strategy to prevent or control their manifestations. Several decades of pharmacological development have failed to deliver a disease-modifying solution to OA. This editorial article outlines the lacunae in the research efforts of the past, the challenges that we are facing at present, and the exciting opportunities we have in the future for the management of OA. OA research has to be made more personalized concerning the phenotypic and endotypic disease variants. To begin with, robust disease classification criteria need to be defined for early OA, and biomarkers to detect such early diseases to aid in patient stratification. We also need to refine our clinical research design to make them more objective to meet the demands of the patient and the regulatory agencies. Embracing the current technologies such as artificial intelligence along with the use of genomic profiling from the omics platforms, the future of OA is more promising in developing appropriate management of OA.

show abstract

The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine

Cited by 24 publications

References 19 publications

Five-Year Outcomes After Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stromal Cells for Repair of Knee Chondral Lesions

Five-Year Outcomes After Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stromal Cells for Repair of Knee Chondral Lesions

Designing polymers for cartilage uptake: effects of architecture and molar mass

Osteoarthritis, an old wine in a new bottle!

Contact Info

Product

Resources

About