“…Further, high sensitivity is required for detecting residual symptomatology, which was found to characterize the majority of patients who were judged to be remitted according to DSM criteria and no longer in need of active treatment [39]. Excessive reliance on symptoms that are part of diagnostic criteria of mental disorders (e.g., major depressive disorder, generalized anxiety disorder) has impoverished clinical assessment in psychopharmacology and does not reflect the broad spectrum of variables that affect clinical presentations: subclinical distress [39], such as demoralization and irritable mood [40], psychological well-being and euthymia [41,42,43], mental pain [44,45,46,47], social adjustment [48], and neuroticism [49,50]. …”