Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other body parts. Till now we have many drugs for the treatment of cancer which are available in branded and generic versions. In the present research, we studied about the difference between the branded and generic drugs in terms of their cost effectiveness, adverse effects, drug interactions, contraindications of the drugs used for cancer. we have collected the data from various retail pharmacies, authorized web sources and from up to date software. In our research we identified that the generic drugs shows huge variation in terms of cost effectiveness, adverse reactions, drug interactions & contraindications when compared with the branded one. This information provides us to choose better therapeutic approach towards cancer treatment.