The condition of lipid metabolism, hemostasis and general homocysteine level as a manifestation of endothelial dysfunction at progressing course of atherosclerosis obliterans of the lower extremities

Abstract

Abstract:The problems related to studying predictors of atherosclerosis obliterans (ASO) of the lower extremities are quite relevant due to high disability and lethality rate of patients belonging to this group. This study aimed to evaluate the values of lipid profile, general homocysteine and hemostasis in relation to the clinical course of ASO. Material and Methods -55 patients with ASO of the lower extremities were divided into two groups: 30 patients with no progressive clinical course, 25 patients with progressive clinical course. The group division was based on the anamnesis (duration of the disease, decrease of painless walking distance during the year, the length of effect lasting from conservative treatment). Data presented as median with lower and upper quartiles -Me (LQ, UQ). Results -As a result of research, there was a registration of moderate hyperhomocysteinemia -23.6 (20.1, 26.4) mkmol/l, as well as high values of triglycerides -2.10 (1.72, 2.51) mmol/l and low-density lipoproteins -4.48 (3.95, 6.44) mmol/l, against low values of high-density lipoproteins -1.14 (0.72, 1.40) mmol/l in lipid profile. Development of hypercoagulability and susceptibility to thrombosis in patients is manifestation of endothelial dysfunction, which plays a key role in progression of ASO of the lower extremities. Keywords: atherosclerosis obliterans, progressive course, hemostasis, lipid profile, homocysteineCite as Dunaevskaya SS, Antufrieva DA. The condition of lipid metabolism, hemostasis and general homocysteine level as a manifestation of endothelial dysfunction at progressing course of atherosclerosis obliterans of the lower extremities.