An adequate surface is essential in ensuring a solid bond between the metal and dental ceramics for metal framework wettability. This work is aimed at investigating the effect of variable abrasive blasting parameters on Ni-Cr alloy surface’s ability to be wetted with liquid ceramics at elevated temperatures. One-hundred and sixty-eight samples were divided into 12 groups (n = 14), which were sandblasted using variable parameters: type of abrasive (Al2O3 and SiC), the grain size of the abrasive (50, 110, and 250 µm), and processing pressure (400 and 600 kPa). After treatment, the samples were cleaned in an ultrasonic cleaner and dried under compressed air. Dental ceramics were applied to the prepared surfaces via drops, and the wettability was tested in a vacuum oven at temperatures in the range of 850–1000 °C. The results were statistically analyzed using ANOVA (α = 0.05). For all surfaces, the contact angles were less than 90° at temperatures below 875 °C. For Al2O3, the best wettability was observed for the smallest particles and, for SiC, the largest particles. The ability to wet the surface of a Ni-Cr alloy is related to its sandblasting properties, such as roughness or the percentage of embedded abrasive particles. It should not be the only factor determining the selection of abrasive blasting parameters when creating a prosthetic restoration.