Today, as the soft power of culture is becoming more and more important, it is very important to pay attention to the learning and dissemination of culture. As the carrier of this process, the use of advanced technology to improve the museum is of great significance. This paper studies the digital design of smart museum based on artificial intelligence in order to explore the application of smart museum in artificial intelligence, analyze the spatial design of smart museum by using digital technology, explore a feasible method to give full play to the function of smart museum, and put forward some suggestions on the spatial design of smart museum. The design of the smart museum is no longer restricted by time and space and uses digital technology to double use virtual things and dynamic space. Through the detailed analysis of the application of artificial intelligence and digitization in the spatial design of the smart museum, combined with the information decision tree algorithm and data heterogeneous network algorithm, this study constructs the model of the information processing architecture of smart museum and the requirements of digital museum and makes a decision-making analysis of the comparison results of existing data. It includes the digital design of smart museum display technology, display effect, and other display-related contents. Analyzing the impact of smart museum on the object can provide data support for the feasibility of digital space design of smart museum based on artificial intelligence. The results of regression data processing show that the spatial visual sense of digital design wisdom museum is very strong, reaching the level of 5.0, and the picture aesthetic effect is up to 4.8.