The configuration of (−) tropic acid and of its naturally occurring esters

Fodor, Gyula; Csepreghy, G.

doi:10.1016/s0040-4039(01)82727-1

Cited by 8 publications

(1 citation statement)

References 3 publications

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“…With carbon‐14–labeled racemic tropic acid in hand, a crystallization process was developed to separate the ( S )‐enantiomer or l ‐tropic acid along with a chiral high‐performance liquid chromatography (HPLC) method. It is worth mentioning that enzymatic chiral resolution of tropic acid has been reported . Different solvent systems were used to evaluate the chiral separation of racemic tropic acid using d ‐(−)‐ threo ‐2‐amino‐1‐(4‐nitrophenyl)‐1,3‐propanediol ( 8 ) as a resolving reagent .…”

Section: Resultsmentioning

confidence: 99%

Buscopan labeled with carbon‐14 and deuterium

Latli

Stiasni

Hrapchak

et al. 2016

Labelled Comp Radiopharmac

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Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon-14- and deuterium-labeled Buscopan was developed using scopolamine, n-butyl-1- C bromide, and n-butyl- H bromide, respectively. In a second carbon-14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety to follow its metabolism. Herein, we describe the detailed preparations of carbon-14- and deuterium-labeled Buscopan.

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Section: Resultsmentioning

confidence: 99%

Buscopan labeled with carbon‐14 and deuterium

Latli

Stiasni

Hrapchak

et al. 2016

Labelled Comp Radiopharmac

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Anticholinergic Drugs

Sastry¹

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter contains information on various anticholinergic agents that block the stimulation of muscarinic receptors by acetylcholine. These include solanaceous alkaloids as well as various types of synthetic anticholinergic agents that are used as antispasmodics, antiulcer agents, mydriatics, and cycloplegics. The structure‐activity relationships of various agents, biocomparative methods for pharmacological evaluation, and their users are also discussed.

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