The Configurational Stability of Triorganostannyl‐Transition Metal Compounds

Gielen, Marcel; Eynde, Ivan Vanden

doi:10.1002/ijch.198000057

Cited by 18 publications

(2 citation statements)

References 42 publications

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“…28 Triorganotin-transition metal complexes like (C 6 H 5 )(CH 3 ) 2 Sn-Fe(h 5 -C 5 H 5 )(CO)P(C 6 H 5 ) 3 or (CH 3 (C 6 H 5 )(CH 3 (C 6 H 5 )CH-CH 2 )SnML n (ML n = Fe(CO) 2 , Mn(CO) 5 or Co(CO) 3 P(C 6 H 5 ) 3 are configurationally stable within the NMR time scale. [29][30][31][32][33] This is also the case for methylneophylphenylstannylcyclopentadienyltricarbonylmanganese.…”

Section: Stereochemistry At Tin Of S N 2 Reactions At a Tetrahedrallymentioning

confidence: 83%

An Overview of Forty Years Organotin Chemistry Developed at the Free Universities of Brussels ULB and VUB

Gielen

2004

ChemInform

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Esta revisão cobre os principais eixos de pesquisa desenvolvidos nas Universidades Livres de Bruxelas entre 1961 e 2001. Primeiro, introduzimos os conceitos desenvolvidos no campo das reações de quebra das ligações carbono-estanho em compostos RR'R"R"'Sn usando reagentes E-N, obtendo-se R-E e R'R"R"'SnN, em solventes nucleofilos e não nucleofilos. A adição do nucleofilo ao íon metálico é necessária para permitir a quebra da ligação metal-carbono pelo eletrofilo. A reação pode ser caracterizada pela retenção da configuração do carbono quando um retentor cíclico é usado, ou pela inversão de configuração quando este retentor não é efetivo. A estéreo-seletividade de substituições nucleofilas bimoleculares em estanho é também discutida, bem como a (in)estabilidade de várias classes de tri-organo-estanho derivados. Finalmente, a atividade in vitro anti-tumoral promissora dos compostos di-e tri-organo-estanhos solúveis em água é referenciada.This review covers the main axes of research developed at the Free Universities of Brussels between 1961 and 2001. This paper first introduces the concepts developed in the field of the cleavage reactions of carbon-tin bonds of RR'R"R"'Sn compounds by E-N reagents yielding R-E and R'R"R"'SnN in non-nucleophilic and nucleophilic solvents. The addition of a nucleophile at the metal atom is needed for allowing the electrophile to cleave the carbon-metal bond. The reaction can be characterized by retention of configuration at carbon when a cyclic constraint is imposed, or by inversion of configuration when such a constraint is not effective. The stereoselectivity at tin of bimolecular nucleophilic substitutions at tin is also discussed as well as the optical (in)stability of several classes of triorganotin derivatives. In the last part of this review, the promising in vitro antitumour activities of water-soluble di-and triorganotin compounds is covered.

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Section: Stereochemistry At Tin Of S N 2 Reactions At a Tetrahedrallymentioning

confidence: 83%

An Overview of Forty Years Organotin Chemistry Developed at the Free Universities of Brussels ULB and VUB

Gielen

2004

ChemInform

Self Cite

View full text Add to dashboard Cite

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Section: Stereochemistry At Tin Of S N 2 Reactions At a Tetrahedrallymentioning

confidence: 83%

An overview of forty years organotin chemistry developed at the Free Universities of Brussels ULB and VUB

Gielen¹

2003

J. Braz. Chem. Soc.

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Esta revisão cobre os principais eixos de pesquisa desenvolvidos nas Universidades Livres de Bruxelas entre 1961 e 2001. Primeiro, introduzimos os conceitos desenvolvidos no campo das reações de quebra das ligações carbono-estanho em compostos RR'R"R"'Sn usando reagentes E-N, obtendo-se RE e R'R"R"'SnN, em solventes nucleofilos e não nucleofilos. A adição do nucleofilo ao íon metálico é necessária para permitir a quebra da ligação metal-carbono pelo eletrofilo. A reação pode ser caracterizada pela retenção da configuração do carbono quando um retentor cíclico é usado, ou pela inversão de configuração quando este retentor não é efetivo. A estéreo-seletividade de substituições nucleofilas bimoleculares em estanho é também discutida, bem como a (in)estabilidade de várias classes de tri-organo-estanho derivados. Finalmente, a atividade in vitro anti-tumoral promissora dos compostos die tri-organo-estanhos solúveis em água é referenciada. This review covers the main axes of research developed at the Free Universities of Brussels between 1961 and 2001. This paper first introduces the concepts developed in the field of the cleavage reactions of carbon-tin bonds of RR'R"R"'Sn compounds by E-N reagents yielding RE and R'R"R"'SnN in non-nucleophilic and nucleophilic solvents. The addition of a nucleophile at the metal atom is needed for allowing the electrophile to cleave the carbon-metal bond. The reaction can be characterized by retention of configuration at carbon when a cyclic constraint is imposed, or by inversion of configuration when such a constraint is not effective. The stereoselectivity at tin of bimolecular nucleophilic substitutions at tin is also discussed as well as the optical (in)stability of several classes of triorganotin derivatives. In the last part of this review, the promising in vitro antitumour activities of water-soluble di-and triorganotin compounds is covered.

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From Tin(IV) and Organotin Halides

Newlands¹

1991

Inorganic Reactions and Methods

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The Configurational Stability of Triorganostannyl‐Transition Metal Compounds

Cited by 18 publications

References 42 publications

An Overview of Forty Years Organotin Chemistry Developed at the Free Universities of Brussels ULB and VUB

An Overview of Forty Years Organotin Chemistry Developed at the Free Universities of Brussels ULB and VUB

An overview of forty years organotin chemistry developed at the Free Universities of Brussels ULB and VUB

From Tin(IV) and Organotin Halides

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