The congenital toxoplasmosis burden in Brazil: Systematic review and meta-analysis

Strang, Ana Gabriela Gomes Ferrari; Ferrari, Rafaela Gomes; Rosário, Denes K. do; Nishi, Letícia; Evangelista, Fernanda Ferreira; Santana, Priscilla Laet; Souza, Aloísio Henrique Pereira de; Mantelo, Francini Martini; Falavigna-Guilherme, Ana Lúcia

doi:10.1016/j.actatropica.2020.105608

Cited by 36 publications

(27 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Central arguments are the cost-benefit ratio [ 7 , 19 , 66 ] and the induction of anxiety as a consequence of an early diagnosis in the absence of curative treatment options [ 57 ]. In moderate prevalence areas with predominantly type II strains and in high prevalence areas with atypical virulent strains, prenatal screening has been reported cost-effective as compared to neonatal screening or to the absence of screening [ 67 , 68 , 69 ]. A recent prospective multicenter randomized trial compared prenatal therapy with pyrimethamine + sulfadiazine (PY/SA) vs. spiramycin to reduce placental transmission of toxoplasmosis and showed a trend toward lower transmission with PY/SA, although it did not reach statistical significance, possibly because of a lack of statistical power [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes in Children with Congenital Toxoplasmosis—A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Even in the absence of manifestations at birth, children with congenital toxoplasmosis (CT) may develop serious long-term sequelae later in life. This systematic review aims to present the current state of knowledge to base an informed decision on how to optimally manage these pregnancies and children. For this, a systematic literature search was performed on 28th July 2022 in PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar and Scopus to identify all prospective and retrospective studies on congenital toxoplasmosis and its long-term outcomes that were evaluated by the authors. We included 31 research papers from several countries. Virulent parasite strains, low socioeconomic status and any delay of treatment seem to contribute to a worse outcome, whereas an early diagnosis of CT as a consequence of prenatal screening may be beneficial. The rate of ocular lesions in treated children increases over time to 30% in European and over 70% in South American children and can be considerably reduced by early treatment in the first year of life. After treatment, new neurological manifestations are not reported, while ocular recurrences are observed in more than 50% of patients, with a mild to moderate impact on quality of life in European cohorts when compared to a significantly reduced quality of life in the more severely affected South American children. Though CT is rare and less severe in Europe when compared with South America, antenatal screening is the only effective way to diagnose and treat affected individuals at the earliest possible time in order to reduce the burden of disease and achieve satisfying outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes in Children with Congenital Toxoplasmosis—A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This result can be explained by the region's high refugee population, climate characteristics and eating habits (17). without antenatal screening, these cases will remain undiagnosed and untreated (23,24). The results of a recent review support the need for universal screening of pregnant women during the gestation period in order to decrease vertical transmission (10).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii infection in pregnant population re-visited; changing trends and call for action

Takmaz¹

2020

Erciyes Med J

View full text Add to dashboard Cite

“…Parasitic infections are a major public health concern because they impact morbidity rates. Among such infections, toxoplasmosis, a foodborne zoonotic infection caused by Toxoplasma gondii [ 6 ], stands out. It has severe clinical manifestations in immunocompromised patients, fetuses, and newborns [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among such infections, toxoplasmosis, a foodborne zoonotic infection caused by Toxoplasma gondii [ 6 ], stands out. It has severe clinical manifestations in immunocompromised patients, fetuses, and newborns [ 6 , 7 ]. Regarding treatment, sulfadiazine combined with pyrimethamine (SDZ + PYR) is the first choice; however, although this option suppresses active infection, it does not cure latent infection [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial, Antivirulence, and Antiparasitic Potential of Capsicum chinense Jacq. Extracts and Their Isolated Compound Capsaicin

et al. 2022

View full text Add to dashboard Cite

Bacterial, fungal, and parasitic infections increase morbimortality rates and hospital costs. This study aimed to assess the antimicrobial and antiparasitic activities of the crude extract from the seeds and peel of the pepper Capsicum chinense Jacq. and of the isolated compound capsaicin and to evaluate their ability to inhibit biofilm formation, eradicate biofilm, and reduce hemolysin production by Candida species. The crude ethanolic and hexane extracts were obtained by maceration at room temperature, and their chemical compositions were analyzed by liquid chromatography coupled to mass spectrometry (LC–MS). The antimicrobial activity of the samples was evaluated by determining the minimum inhibitory concentration. Inhibition of biofilm formation and biofilm eradication by the samples were evaluated based on biomass and cell viability. Reduction of Candida spp. hemolytic activity by the samples was determined on sheep blood agar plates. The antiparasitic action of the samples was evaluated by determining their ability to inhibit Toxoplasma gondii intracellular proliferation. LC–MS-ESI analyses helped to identify organic and phenolic acids, flavonoids, capsaicinoids, and fatty acids in the ethanolic extracts, as well as capsaicinoids and fatty acids in the hexane extracts. Antifungal action was more evident against C. glabrata and C. tropicalis. The samples inhibited biofilm formation and eradicated the biofilm formed by C. tropicalis more effectively. Sub-inhibitory concentrations of the samples significantly reduced the C. glabrata and C. tropicalis hemolytic activity. The samples only altered host cell viability when tested at higher concentrations; however, at non-toxic concentrations, they reduced T. gondii growth. In association with gold standard drugs used to treat toxoplasmosis, capsaicin improved their antiparasitic activity. These results are unprecedented and encouraging, indicating the Capsicum chinense Jacq. peel and seed extracts and capsaicin display antifungal and antiparasitic activities.

show abstract

The congenital toxoplasmosis burden in Brazil: Systematic review and meta-analysis

Cited by 36 publications

References 62 publications

Long-Term Outcomes in Children with Congenital Toxoplasmosis—A Systematic Review

Long-Term Outcomes in Children with Congenital Toxoplasmosis—A Systematic Review

Seroprevalence of Toxoplasma gondii infection in pregnant population re-visited; changing trends and call for action

Antimicrobial, Antivirulence, and Antiparasitic Potential of Capsicum chinense Jacq. Extracts and Their Isolated Compound Capsaicin

Contact Info

Product

Resources

About