The Connection between Climate Change, Surgical Care and Neglected Tropical Diseases

Shirley, Hugh; Grifferty, Grace; Yates, Elizabeth; Raykar, Nakul; Wamai, Richard G.; McClain, Craig D.

doi:10.5334/aogh.3766

Cited by 10 publications

(4 citation statements)

References 20 publications

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“…Climate change is positioned to impact the prevalence and distribution of LF through altered vector and transmission dynamics [ 59 ]. These mechanisms include changes in temperature and precipitation, which are key parameters in defining the geospatial distribution of LF across which the disease can occur [ 60 ].…”

Section: Ongoing and Future Challengesmentioning

confidence: 99%

Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination

Chimfwembe,

Shirley,

Baker

et al. 2024

TropicalMed

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The establishment of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) to stop the transmission of infection has significantly reduced the incidence of lymphatic filariasis, a debilitating mosquito-borne neglected tropical disease. The primary strategies that have been employed include mass drug administration (MDA) of anthelminthics and morbidity management and disability prevention (MMDP). While some countries have been able to reach elimination status in Africa, there is still active transmission of LF in Zambia. The nematode responsible for the disease is Wuchereria bancrofti, which is transmitted by Anopheles mosquitoes. To alleviate the suffering of those infected by the disease, the Zambian Ministry of Health launched a program to eliminate LF as a public health problem in 2003. This project reviewed the efforts to achieve the elimination of LF in Zambia, past and present government policies, and the anticipated challenges. MDAs have been conducted since 2014 and coverage has been between 87% and 92%. Zambia has now moved towards pre-transmission assessment surveys (PRETAS) and transmission assessment surveys (TAS). MMDP is a major priority and planned to be conducted between 2022 and 2026. COVID-19 presented a new challenge in the control of LF, while climate change, immigration, co-infections, and funding limitations will complicate further progress.

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Section: Ongoing and Future Challengesmentioning

confidence: 99%

Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination

Chimfwembe,

Shirley,

Baker

et al. 2024

TropicalMed

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“…Additionally, a growing body of research links environmental pollution to the emergence of additional cancers, including bladder and breast cancer (Turner et al, 2020). Warmer weather, excessive rain, and flooding can also exacerbate illnesses that require surgery, such as trachoma, filariasis, fungal and parasite infections, and infections of the eyes and skin (Shirley et al, 2022). Acute myocardial infarction mortality may be elevated by extreme temperature events, air pollution, and even long-term stress resulting from severe natural catastrophes (Xu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

effect of training program on improving awareness regarding climate change-related disasters among hospitalized patients undergoing surgical procedure

Mahmoud,

Farag,

Rahman

et al. 2022

ijhs

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Climate change is impacting human lives and health in a variety of ways. It threatens the essential ingredients of good health as; clean air, safe drinking water, nutritious food supply, and safe shelter, and has the potential to undermine decades of progress in global health. Hospitals have a very important role in responding to disasters. Patients' improvement of their knowledge and practices helps them to better outcomes in disasters. This study aimed to investigate the effect of training programs on improving awareness regarding climate change-related disasters among hospitalized patients undergoing surgical procedures. Design: To achieve the aim of the current study quasi-experimental design was used (with a pre-test post-test design on a group). Setting: The study was conducted at the surgical department at Ain Shams University Hospital. Sampling: A total of 100 hospitalized patients undergoing surgical procedures were selected from previous settings based on convenient sampling. Tool I: Structured questionnaire; composed of two parts. Part 1: Patients' data. Part 2: Patients' knowledge regarding climate change, Tool II: Patients' reported practices questionnaire, and Tool III: Patients' awareness of climate change questionnaire.

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“…These diseases represent a significant global health problem and threaten millions of people, particularly in developing countries. Despite being highly prevalent in tropical and subtropical regions, climate changes are expected to adversely impact the transmission dynamics of vector-borne diseases and shift the disease burden across the world . HAT is caused by infection with two subspecies of the protozoan parasite Trypanosoma brucei (T.…”

mentioning

confidence: 99%

Discovery of 1,3,4-Oxadiazole Derivatives as Broad-Spectrum Antiparasitic Agents

Corfu,

Santarem,

Luelmo

et al. 2024

ACS Infect. Dis.

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Vector-borne parasitic diseases (VBPDs) pose a significant threat to public health on a global scale. Collectively, Human African Trypanosomiasis (HAT), Leishmaniasis, and Malaria threaten millions of people, particularly in developing countries. Climate change might alter the transmission and spread of VBPDs, leading to a global burden of these diseases. Thus, novel agents are urgently needed to expand therapeutic options and limit the spread of drugresistant parasites. Herein, we report the development of broad-spectrum antiparasitic agents by screening a known library of antileishmanial and antimalarial compounds toward Trypanosoma brucei (T. brucei) and identifying a 1,3,4-oxadiazole derivative (19) as anti-T. brucei hit with predicted blood−brain barrier permeability. Subsequently, extensive structure−activity−relationship studies around the lipophilic tail of 19 led to a potent antitrypanosomal and antimalarial compound (27), with moderate potency also toward Leishmania infantum (L. infantum) and Leishmania tropica. In addition, we discovered a pan-active antiparasitic molecule (24), showing low-micromolar IC 50 s toward T. brucei and Leishmania spp. promastigotes and amastigotes, and nanomolar IC 50 against Plasmodium falciparum, together with high selectivity for the parasites over mammalian cells (THP-1). Early ADME-toxicity assays were used to assess the safety profile of the compounds. Overall, we characterized 24 and 27, bearing the 1,3,4-oxadiazole privileged scaffold, as broad-spectrum low-toxicity agents for the treatment of VBPDs. An alkynesubstituted chemical probe (30) was synthesized and will be utilized in proteomics experiments aimed at deconvoluting the mechanism of action in the T. brucei parasite.

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The Connection between Climate Change, Surgical Care and Neglected Tropical Diseases

Cited by 10 publications

References 20 publications

Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination

Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination

effect of training program on improving awareness regarding climate change-related disasters among hospitalized patients undergoing surgical procedure

Discovery of 1,3,4-Oxadiazole Derivatives as Broad-Spectrum Antiparasitic Agents

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