2015
DOI: 10.1038/nrn3901
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The connectomics of brain disorders

Abstract: Pathological perturbations of the brain are rarely confined to a single locus; instead, they often spread via axonal pathways to influence other regions. Patterns of such disease propagation are constrained by the extraordinarily complex, yet highly organized, topology of the underlying neural architecture; the so-called connectome. Thus, network organization fundamentally influences brain disease, and a connectomic approach grounded in network science is integral to understanding neuropathology. Here, we cons… Show more

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Cited by 1,487 publications
(1,256 citation statements)
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References 172 publications
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“…Neglect is mostly associated with a lesion-induced reorganization of the neocortical frontal-parietal networks of the right hemisphere (RH) [117,118]. It can be seen as a network deficit due to diaschisis [119] showing a slowing of the EEG [120] that can be explained in terms of TCD [121]. Interestingly, about 82% of RH patients and 62% of left hemisphere (LH) stroke patients suffer from spatial neglect during the first days after stroke.…”
Section: (A) the Neuronal Substrate Of Consciousnessmentioning
confidence: 99%
“…Neglect is mostly associated with a lesion-induced reorganization of the neocortical frontal-parietal networks of the right hemisphere (RH) [117,118]. It can be seen as a network deficit due to diaschisis [119] showing a slowing of the EEG [120] that can be explained in terms of TCD [121]. Interestingly, about 82% of RH patients and 62% of left hemisphere (LH) stroke patients suffer from spatial neglect during the first days after stroke.…”
Section: (A) the Neuronal Substrate Of Consciousnessmentioning
confidence: 99%
“…CN subjects were recruited via print and electronic media, and noticeboards in universities and local communities. Sample ascertainment and separate clinical assessments for younger (15)(16)(17)(18)(19)(20)(21) and older (22)(23)(24)(25)(26)(27)(28)(29)(30) age categories are provided in Perich et al 36 and in Supplementary Information 1.1. We pooled data across both age cohorts unless there was a specific correlation between a brain network measure and an age-specific clinical variable in either group.…”
Section: Materials and Methods Participantsmentioning
confidence: 99%
“…The application of graph theoretical techniques to these networks has shown that healthy brain networks demonstrate 'small-world' features (indicative of balanced integration and segregation), minimising total fibre length. 2,26,27 Such organisational properties appear to be compromised in many disorders, 26 exemplified by the burgeoning connectomic research elucidating network aberrations in schizophrenia. 28,29 Disturbances appear to involve highly connected hub regions, 10,30 in particular those hub-regions with dense wiring among themselves, known as the 'rich club'.…”
Section: Introductionmentioning
confidence: 99%
“…Extending network research in fMRI from functional to effective connectivity could provide a substantial advance to the understanding of brain dynamics in health and disease (Bielczyk, Buitelaar, Glennon, & Tiesinga, 2015; Fornito, Zalewsky, & Breakspear, 2015; Friston, 2011; Sporns, 2014). Effective connectivity in fMRI is a complex research problem that involves not only specification of the presence or absence of connections, but also the directionality of the information flow.…”
Section: Introductionmentioning
confidence: 99%