The consequences of potassium depletion

Welt, Louis G.; Hollander, William; Blythe, William B.

doi:10.1016/0021-9681(60)90038-2

Cited by 113 publications

(25 citation statements)

References 162 publications

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“…In the A pH greater than 0.25 group this decrease in percentage of potassium comprising total cation exchange (49 ±o8% SE) is far greater than the percentage decrease in serum potassium (14 +3% SE), or estimated decrease in total body potassium (6 ±0.4% SE).' It presumably is also far greater than the decrease in intracellular and more specifically renal tubular potassium concentration (35). Therefore some mechanism other than a change in potassium concentration in some body compartment appears to be necessary to explain fully the decrease in K+/(k++H+) ratio.…”

Section: Potassium Depletion and Urine Acidification 815mentioning

confidence: 99%

The effect of uncomplicated potassium depletion on urine acidification

Tannen¹

1970

J. Clin. Invest.

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Section: Potassium Depletion and Urine Acidification 815mentioning

confidence: 99%

The effect of uncomplicated potassium depletion on urine acidification

Tannen¹

1970

J. Clin. Invest.

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“…Kaliopenic nephropathy is now a well recognized entity in which diminished ability to concentrate urine is a prominent clinical feature (1)(2)(3)(4). Most instances are reported in patients with an aldosterone-producing tumor or chronic diarrhea (5), and the defect in urine concentrating ability was well established when potassium deficiency was recognized.…”

mentioning

confidence: 99%

Water Excretion in Potassium-Deficient Man*

Rubini¹

1961

J. Clin. Invest.

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“…4) indicates that changes in the state of hydration were not responsible for the changes in clearances. It has been proposed that the changes in filtration rate that occur in potassium deficiency can be explained by partial obstruction of nephrons due to lesions in the collecting ducts (14). However, whereas such lesions have been described in the rat (15) ficiencv on glucose Tm have been reported.…”

Section: Resultsmentioning

confidence: 99%

Effects of potassium deficiency on renal function in the dog

Abbrecht¹

1969

J. Clin. Invest.

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A B S T R A C T Serial determinations of the renal clearance for inulin and para-aminohippuric acid (PAH), maximum renal tubular reabsorptive rate for glucose, maximum urinary concentrating ability, total exchangeable potassium, extracellular volume, and plasma sodium and potassium concentrations were done in seven dogs before and after dietary potassium depletion. The same measurements were also made in two of the dogs during potassium repletion.Inulin and PAH clearances and transport maxima for glucose decreased progressively during depletion. These changes correlated well with both the duration of depletion and the extent of depletion as measured by total exchangeable potassium. Decreases in inulin and PAH clearance closely paralleled each other, suggesting that there might be a renal hemodynamic basis for both effects. The decreases in transport maxima for glucose were greater than those for inulin or PAH clearance, indicating the presence of a defect in the cellular transport mechanism for glucose. In the dogs that were repleted, renal function gradually returned to the predepletion state. No significant changes were found in extracellular volume or plasma sodium concentration during depletion. Renal concentrating ability decreased only moderately during depletion, with the decrease correlating better with plasma potassium concentration than with total exchangeable potassium. This finding contrasts with the marked decrease in concentrating ability and the severe polydipsia and polyuria found in animals depleted of potassium with the aid of corticosteroids. The results of the present study emphasize the importance of considering species differences and the method of producing depletion in interpreting studies of the effects of hypokalemia on renal function.

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The consequences of potassium depletion

Cited by 113 publications

References 162 publications

The effect of uncomplicated potassium depletion on urine acidification

The effect of uncomplicated potassium depletion on urine acidification

Water Excretion in Potassium-Deficient Man*

Effects of potassium deficiency on renal function in the dog

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