Karon's work with Mr. X reflects the model that he and I use generally in doing psychoanalytic psychotherapy with schizophrenic patients. In my experience, this work is frequently met with considerable skepticism and at times outright antagonism from the professional mental health community. In this commentary I explore 10 possible reasons for these negative reactions and why I believe the reactions are off target from the central clinical fact that Karon's model has a track record of success. These reasons include such areas as the roles of diagnosis, medication, a detailed developmental history, the therapist's distinctive personality and style, and the therapist's level of activity in treating patients diagnosed as schizophrenic.key words: schizophrenia; psychoanalytic treatment ____________________________________________________________________________ It was enjoyable and informative to read the clinical case study of Mr. X by Bertram Karon (2008). I have known Dr. Karon since 1967, and I have heard him present in lectures, seminars, and at conferences many times. As I read his words, I can "hear" him saying them. As always, I hear his depth of understanding and appreciation of the experiential world in which an individual with schizophrenia lives, and I hear his intense efforts to help build a "safe world" in which the patient with schizophrenia can feel less threatened and start tentatively and inconsistently to relate and communicate with the therapist, initially in a vague, complex, and difficult to understand manner. I have found his style, technique, and his actual words in such therapy to be very helpful to the typically terrified individuals with schizophrenia. Dr. Karon influenced me early in my training in conjunction with my role as the Senior Research Coordinator on the program he directed, the below-described "Michigan State Psychotherapy with Schizophrenics Project." Much of my clinical style with severely disturbed patients is modeled after him. My own clinical success with schizophrenic patients is likewise similar to his, and I have lectured broadly on the psychotherapeutic process of treating individuals with