The conserved cellular roles of CLN proteins: Novel insights from Dictyostelium discoideum

Remtulla, Adam A.N.; Huber, Robert J.

doi:10.1016/j.ejcb.2023.151305

Cited by 2 publications

(1 citation statement)

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“…CLN proteins are distributed throughout the endomembrane system and regulate a variety of cellular processes related to ion homeostasis, autophagy, lipid metabolism, and protein trafficking [ 125 ]. To date, fourteen CLN proteins (CLN1-14) have been identified and characterized [ 126 , 127 ].…”

Section: Lysosomal Ion Channelsmentioning

confidence: 99%

Pathological Functions of Lysosomal Ion Channels in the Central Nervous System

Cen,

Hu,

Shen

et al. 2024

IJMS

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Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl−, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets.

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Section: Lysosomal Ion Channelsmentioning

confidence: 99%