2012
DOI: 10.1523/jneurosci.1638-12.2012
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The Conserved Dopaminergic Diencephalospinal Tract Mediates Vertebrate Locomotor Development in Zebrafish Larvae

Abstract: The most conserved part of the vertebrate dopaminergic system is the orthopedia (otp)-expressing diencephalic neuronal population that constitutes the dopaminergic diencephalospinal tract (DDT). While studies in the neonatal murine spinal cord in vitro suggest an early locomotor role of the DDT, the function of the DDT in developing vertebrates in vivo remains unknown. Here, we investigated the role of the DDT in the locomotor development of zebrafish larvae. To assess the development of the behavioral and neu… Show more

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Cited by 137 publications
(188 citation statements)
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References 47 publications
(92 reference statements)
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“…We find that the axons and their synaptic terminals of OB output neurons are closely associated with processes of dopaminergic neurons in the PT, rendering them a strong candidate for postsynaptic partner. Because a population of dopaminergic neurons in the PT send descending axons directly to the spinal cord 37 , it is conceivable that the OB-PT pathway may play general roles in olfaction such as evoking locomotion 47,48 . Further studies are required to precisely identify types of PT neurons connecting with the OB output neurons and to elucidate the functional aspects of this unique neural circuitry.…”
Section: Discussionmentioning
confidence: 99%
“…We find that the axons and their synaptic terminals of OB output neurons are closely associated with processes of dopaminergic neurons in the PT, rendering them a strong candidate for postsynaptic partner. Because a population of dopaminergic neurons in the PT send descending axons directly to the spinal cord 37 , it is conceivable that the OB-PT pathway may play general roles in olfaction such as evoking locomotion 47,48 . Further studies are required to precisely identify types of PT neurons connecting with the OB output neurons and to elucidate the functional aspects of this unique neural circuitry.…”
Section: Discussionmentioning
confidence: 99%
“…Swimming frequency is also the parameter that can most easily be compared between free and fictive swimming. This has been done in larval bullfrogs (Stehouwer and Farel, 1980), newt embryos (Soffe et al, 1983), larval angelfish (Yoshida et al, 1996), zebrafish (Lambert et al, 2012b) and young Xenopus tadpoles, and in all these cases, free and fictive swimming were found to be at least qualitatively similar. Our current findings add to these previous reports that the swimming frequency is also quantitatively similar between free and fictive swimming, with a gradual developmental decrease of the swim rhythm.…”
Section: −1mentioning
confidence: 98%
“…For example, rod photoreceptors can be ablated in as low as 2.5 mM MTZ for 24 h, 20 while macrophages require 15 h in 5 mM MTZ, 18 and a 3-day treatment in 5-10 mM MTZ was used to ablate dopaminergic neurons. 21 Treatment in 10 mM MTZ for 24 h was used in the initial reports, 9,13 and has become a standard regimen for NTR-mediated ablation of multiple cell types. 2,[9][10][11][12][13]15,22,23 However, 24 h/10 mM MTZ treatments are problematic.…”
Section: Introductionmentioning
confidence: 99%