“…Mef-2, a MADS-box protein, is expressed in all muscle types in a Twi-dependent fashion and plays an essential role in the development of all larval muscles as well as many adult muscles (Nguyen et al, 1994;Bour et al, 1995;Lilly et al, 1995;Ranganayakulu et al, 1995;Bryantsev et al, 2012a;Soler et al, 2012). The activity of Mef-2 is modulated both positively and negatively by a number of co-factors, including Vestigial and Scalloped (Deng et al, 2009), Chorion Factor 2 (Tanaka et al, 2008), Him (Liotta et al, 2007;Elgar et al, 2008;Soler and Taylor, 2009), and Lmd (Cunha et al, 2010).…”