2012
DOI: 10.1242/dev.077875
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The conserved transcription factor Mef2 has multiple roles in adult Drosophila musculature formation

Abstract: SUMMARYMuscle is an established paradigm for analysing the cell differentiation programs that underpin the production of specialised tissues during development. These programs are controlled by key transcription factors, and a well-studied regulator of muscle gene expression is the conserved transcription factor Mef2. In vivo, Mef2 is essential for the development of the Drosophila larval musculature: Mef2-null embryos have no differentiated somatic muscle. By contrast, a similar phenotype has not been seen in… Show more

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Cited by 26 publications
(17 citation statements)
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References 29 publications
(49 reference statements)
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“…The TORC1-4EBP-Mef2 pathway might be involved in other muscle-wasting conditions that affect TOR activity, such as fasting, ageing, and cachexia. By showing that Mef2c regulates muscle fiber growth regardless of any earlier role in myoblast terminal differentiation, our data support the view of Mef2 as a muscle homeostatic regulator [95],[96]. It will be interesting to determine whether translational regulation of human MEF2C is also important in the nervous system, where MEF2C is associated with autism and synaptic regulation [97].…”
Section: Discussionsupporting
confidence: 78%
“…The TORC1-4EBP-Mef2 pathway might be involved in other muscle-wasting conditions that affect TOR activity, such as fasting, ageing, and cachexia. By showing that Mef2c regulates muscle fiber growth regardless of any earlier role in myoblast terminal differentiation, our data support the view of Mef2 as a muscle homeostatic regulator [95],[96]. It will be interesting to determine whether translational regulation of human MEF2C is also important in the nervous system, where MEF2C is associated with autism and synaptic regulation [97].…”
Section: Discussionsupporting
confidence: 78%
“…Mef-2, a MADS-box protein, is expressed in all muscle types in a Twi-dependent fashion and plays an essential role in the development of all larval muscles as well as many adult muscles (Nguyen et al, 1994;Bour et al, 1995;Lilly et al, 1995;Ranganayakulu et al, 1995;Bryantsev et al, 2012a;Soler et al, 2012). The activity of Mef-2 is modulated both positively and negatively by a number of co-factors, including Vestigial and Scalloped (Deng et al, 2009), Chorion Factor 2 (Tanaka et al, 2008), Him (Liotta et al, 2007;Elgar et al, 2008;Soler and Taylor, 2009), and Lmd (Cunha et al, 2010).…”
Section: Somatic Muscle Development In Drosophilamentioning
confidence: 99%
“…Such cooperative interactions of Mef2 to instruct spatio-temporally restricted expression of target genes have also been demonstrated with the fusion competent myoblast-specific transcription factor Lame duck (Lmd) [13], the cardiogenic transcription factor Tinman and the general mesodermal factor Twist [78]. Mef2 is also required for IFM differentiation, being essential for proper formation and maturation of contractile filaments [70]. However, whether cooperative interaction of Salm with Mef2 at enhancers of fibrillar muscle genes occurs awaits further investigation.…”
Section: The Muscle Fiber-type Selector Gene Salmmentioning
confidence: 99%