The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease

Morris, John C.; Heyman, Albert; Mohs, Richard C.; Hughes, James P.; Belle, Gerald van; Fillenbaum, Gerda G.; Mellits, E. David; Clark, Christopher M.

doi:10.1212/wnl.39.9.1159

Cited by 3,486 publications

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“…All the patients with AD who were included in this investigation already had a diagnosis of probable AD, which was confirmed by way of the Consortium to Establish a Registry for Alzheimer's Disease 13 , and all subjects were treated with cholinesterase inhibitors. This study was approved by the Ethics Committee of our university hospital.…”

Section: Methods Participantsmentioning

confidence: 94%

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Pereira

Oliveira

Schultz

et al. 2016

Arq. Neuro-Psiquiatr.

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Currently, there are no studies reporting how much balance impairment coexists with gait apraxia in mild and moderate Alzheimer’s disease (AD). Objectives To assess correlations among gait apraxia, balance impairment and cognitive performance in mild (AD1, n = 30) and moderate (AD2, n = 30) AD. Method The following evaluations were undertaken: gait apraxia (Assessment Walking Skills); balance performance (Berg Balance Scale); Clinical Dementia Rating and Mini-mental State Examination (MMSE). Results While disregarding AD subgroups, Berg Balance Scale and the MMSE correlated significantly with Assessment Walking Skills and 23% of all subjects scored below its cut-off. After stratification, Berg Balance Scale correlated significantly with Assessment Walking Skills in both AD subgroups, and with the MMSE only in AD1. Conclusions Balance impairment does not necessarily coexist with gait apraxia. Gait apraxia is more prevalent in moderate AD when compared with mild AD.

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Section: Methods Participantsmentioning

confidence: 94%

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Pereira

Oliveira

Schultz

et al. 2016

Arq. Neuro-Psiquiatr.

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“…The battery comprised tests previously validated for cross‐cultural settings 17, 18. The following domains were derived by summing standardized individual test scores: global/overall function (Community Screening Instrument for Dementia [CSID] cognitive assessment)19; verbal memory (immediate and delayed verbal recall [CERAD 10‐word]20), visual memory (picture recognition); fluency (animal naming21), processing speed (color trail‐making A and B22); and working memory (forward and backward digit span23). …”

Section: Methodsmentioning

confidence: 99%

Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study

Park

Williams

Chaturvedi

et al. 2017

JAHA

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BackgroundSubclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross‐sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms.Method and ResultsA total of 1338 individuals (69±6 years) from the Southall and Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak systolic wave) and diastolic (left atrial diameter) assessment. Cognitive function was assessed and total and hippocampal brain volumes were measured by magnetic resonance imaging. Global LV function was assessed by circulating N‐terminal pro–brain natriuretic peptide. The role of potential mechanistic pathways of arterial stiffness, atherosclerosis, microvascular disease, and inflammation were explored. After adjusting for age, sex, and ethnicity, lower systolic function was associated with lower total brain (beta±standard error, 14.9±3.2 cm3; P<0.0001) and hippocampal volumes (0.05±0.02 cm3, P=0.01). Reduced diastolic function was associated with poorer working memory (−0.21±0.07, P=0.004) and fluency scores (−0.18±0.08, P=0.02). Reduced global LV function was associated with smaller hippocampal volume (−0.10±0.03 cm3, P=0.004) and adverse visual memory (−0.076±0.03, P=0.02) and processing speed (0.063±0.02, P=0.006) scores. Separate adjustment for concomitant cardiovascular risk factors attenuated associations with hippocampal volume and fluency only. Further adjustment for the alternative pathways of microvascular disease or arterial stiffness attenuated the relationship between global LV function and visual memory.ConclusionsIn a community‐based sample of older people, measures of LV function were associated with structural/functional measures of the brain. These associations were not wholly explained by concomitant risk factors or potential mechanistic pathways.

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“…We selected the Short Blessed Test (SBT) [26], a brief version of the Blessed Information-Memory-Concentration Test [27], as the brief cognitive assessment to identify and exclude patients with significant (SBT > 4) cognitive impairment [28]. The SBT is shorter than other cognitive assessments, such as the MMSE [29] and the MOCA [30].…”

Section: Methodsmentioning

confidence: 99%

Implementation of a brief anxiety assessment and evaluation in a Department of Veterans Affairs geriatric primary care clinic

et al. 2016

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Abstract-Anxiety disorders are common and debilitating in older individuals, yet anxiety is often not formally assessed in primary care. We conducted a quality improvement project to examine the feasibility of implementing a brief anxiety assessment, the Geriatric Anxiety Inventory (GAI), in a Department of Veterans Affairs geriatric primary care clinic. We compared the GAI with a depression assessment, the 15-item Geriatric Depression Scale (GDS-15). Fifty older Veterans (mean age = 78.5 +/-7.4 yr) completed the GAI and GDS-15. Mean completion time and feedback to patients was brief (6.20 min; n = 10). Good internal consistency (alpha = 0.82) was found for GAI scores. Patients with psychiatric diagnoses obtained significantly higher GAI scores (mean = 4.73 +/-1.15) compared with patients without psychiatric diagnoses (mean = 1.15 +/-1.86, t(11.46) = -3.10, p = 0.01). Findings suggest that the GAI is acceptable to patients but may not be suitable for differentiating anxiety symptoms or disorders from depression. Interdisciplinary team members continued to implement the GAI after project completion to screen for and track anxiety symptoms in our geriatric primary care patients. Detecting anxiety with the GAI had the benefit of allowing providers to initiate conversations about available treatments and track symptoms as part of noting treatment progress.

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease

Cited by 3,486 publications

References 0 publications

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study

Implementation of a brief anxiety assessment and evaluation in a Department of Veterans Affairs geriatric primary care clinic

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