2010
DOI: 10.1002/glia.21061
|View full text |Cite
|
Sign up to set email alerts
|

The constitutive production of the endocannabinoid 2‐arachidonoylglycerol participates in oligodendrocyte differentiation

Abstract: Endocannabinoids have recently emerged as instructive cues in the developing central nervous system, and, based on the expression of their receptors, we identified oligodendrocytes as potential targets of these molecules. Here, we show that the enzymes responsible for the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG), diacylglycerol lipase alpha (DAGLα) and beta (DAGLβ), and degradation, monoacylglycerol lipase (MAGL), can be found in oligodendrocytes at different developmental stages. Moreove… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

6
80
0
2

Year Published

2012
2012
2022
2022

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 81 publications
(88 citation statements)
references
References 58 publications
6
80
0
2
Order By: Relevance
“…The concentrations of cannabinoid drugs and other pharmacological reagents used in the present study were selected on the basis of previous reports (reviewed by Pertwee 2005) and according to our own publications where they showed to be effective and specific in our culture system (MolinaHolgado et al 2002;Gomez et al 2010Gomez et al , 2011.…”
Section: Reagentsmentioning
confidence: 99%
See 3 more Smart Citations
“…The concentrations of cannabinoid drugs and other pharmacological reagents used in the present study were selected on the basis of previous reports (reviewed by Pertwee 2005) and according to our own publications where they showed to be effective and specific in our culture system (MolinaHolgado et al 2002;Gomez et al 2010Gomez et al , 2011.…”
Section: Reagentsmentioning
confidence: 99%
“…Primary mixed glial cultures were prepared as described previously (Molina-Holgado et al 2002;Gomez et al 2010) and purified OPCs were plated onto poly-Dlysine-coated culture dishes or coverslips at a density of 40, 000 cells/cm 2 in serum-free defined medium (SFM) containing 5 ng/ml of PDGFAA and b-FGF for 24 h before experiments unless otherwise indicated.…”
Section: Oligodendrocyte Progenitor Cell Culturementioning
confidence: 99%
See 2 more Smart Citations
“…Preclinical studies have demonstrated that cannabinoids can alleviate MS-associated symptoms, such as spasticity (Baker et al, 2000), and they exhibit anti-inflammatory (Arévalo-Martín et al, 2003;Croxford and Miller, 2003), antioxidant, anti-excitotoxic and neuroprotective properties (Pryce et al, 2003;Fernández-Ruiz et al, 2010;Loría et al, 2010). Cannabinoids are also protective to oligodendrocytes in vitro and in vivo (Molina-Holgado et al, 2002;Gómez et al, 2010;Mecha et al, 2012). Sativex ® is an oromucosal spray that contains an equimolecular combination of Δ 9 -tetrahydrocannabinol-botanical drug substance (Δ 9 -THC-BDS) and cannabidiol-botanical drug substance (CBD-BDS) and it has been approved for use in patients with MS-related spasticity and neuropathic pain.…”
Section: Introductionmentioning
confidence: 99%