Amidst the swift advancements in information technology, university-level English education encounters both challenges and opportunities for innovation. This study is dedicated to the development of a system tailored for precise teaching strategies in college English, employing students from M-school as the primary research subjects. Subsequently, the relationship between various teaching strategies and the outcomes of precision teaching was investigated through correlation analysis using SPSS. Furthermore, the factors influencing English performance were analyzed using Pearson’s correlation coefficient and grey correlation analysis within multiple regression analyses. The results show that the overall mean score for English precision teaching is 3.5162, which is in the middle of the teaching level. Furthermore, the significant (two-sided) p-values of the factors affecting the level of English precision teaching and English achievement are less than 0.05, which is significantly correlated with English achievement. College students’ English achievement = 0.534+0.142*Teaching objectives+0.195*Learning situation analysis+0.238*Teaching content+0.271* Teaching methods+0.187*Teaching organization+0.185*Teaching evaluation. The study shows that the precise teaching of English in colleges and universities can be optimized in terms of teaching objectives, learning situation analysis, teaching content, teaching methods, teaching organization form, and teaching evaluation.