The content of proteins in intrauterine lavage for prognosis of efficiency of the IVF program in chronic endometritis

Tretyakova, Ya. N.; Лихачева, Виктория Васильевна; Зорина, В. Н.; Зорина, Р. М.; Renge, L. V.; Tretyakova, T. V.; Маркдорф, Аркадий Геннадьевич; Bazhenova, L. G.

doi:10.17116/repro201723474-80

Cited by 2 publications

(2 citation statements)

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“…An important role in this process is given to iron-containing proteins -lactoferrin (LF) and ferritin (F) [1][2][3][4][5]. Their direct or indirect participation in immune processes is shown -the lower the concentration of LF and F, the lower the "body's immune forces" [4][5][6]. Currently, the following functions of lactoferrin and ferritin are described.…”

Section: Topicalitymentioning

confidence: 99%

“…Currently, the following functions of lactoferrin and ferritin are described. These are iron homeostasis, differentiation, and growth of cells of various types, antimicrobial protection, as well as anti-inflammatory and antitumor properties [3][4][5][6][7]. Immune properties of lactoferrin and ferritin are also actively studied in breast cancer.…”

Section: Topicalitymentioning

confidence: 99%

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The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

2022

IGWHC

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Section: Topicalitymentioning

confidence: 99%

Section: Topicalitymentioning

confidence: 99%

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

2022

IGWHC

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Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study

Gizinger,

Sorokin,

Radzinskiy

2024

Gynecology

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Aim. To determine local features of lipoperoxidation processes, antioxidant defense, state of matrix metalloproteinases in chronic endometritis. Materials and methods. Eighty women aged 29.33±6.71 (min-max [24–36]) with histologically and immunohistochemically confirmed chronic endometritis and a history of reproductive losses were examined (group 1). The control group consisted of 30 patients without chronic endometritis confirmed by the results of a histochemical study and no history of reproductive losses, suffering from infertility of tubal-peritoneal origin at the age of 30.11±6.9 years (min-max [24–37]; group 2). All 130 patients underwent transvaginal echography of the pelvic organs, and histological and immunohistochemical examination of endometrial samples was performed. The activity of lipid peroxidation factors was analyzed: primary, secondary and final products of lipid peroxidation in heptane and isopropanolol fractions of uterine cavity aspirate, enzymes of the antioxidant system: superoxide dismutase, catalase, glutathione peroxidase, deoxyribonuclease I (DNase), by spectrophotometric method, remodeling factors – matrix metalloproteinases MMP-2, -9 by flow fluorimetry. Results. In patients of group 1, according to transvaginal echography of the pelvic organs, M-echo was 6.29±1.22 mm, in group 2 – 9.10±1.15 mm. In chronic endometritis, disruption of pro-oxidant and activity of antioxidant factors in the endometrium in women with chronic endometritis and a history of reproductive losses. In the heptane fraction of the phenolic extract, the concentration of primary products of lipid peroxidation (diene conjugates) was 12.98% higher than in the control, the content of secondary products of lipid peroxidation (ketodienes) was higher by 15.45%, conjugated trienes by 18.67% higher than the values in the control group, which indicates increased lipid peroxidation of endometrial cell membranes during CE. In the isopropanol phase, the products of lipid peroxidation of phospholipid acyl residues are detected. In the isopropanol fraction of the lipid extract, the amount of diene conjugates was higher, ketodienes by 24.32% and conjugated trienes by 26.14%. An increase in the activity of the enzymes superoxide dismutase by 23.98%, catalase by 14.34%, glutathione peroxidase by 12.39%, and DNase by 2.9 times was recorded compared to the indicators of group 2. Conclusion. Chronic endometritis is accompanied by changes in the system of pro-oxidant and antioxidant factors, the content of tissue remodeling products. The pathogenetic changes underlying oxidative stress in the endometrium may be increased leukocyte infiltration, imbalance of primary, secondary and end products of lipid peroxidation, enzymes superoxide dismutase, catalase, glutathione peroxidase, deoxyribonuclease I (DNase), expression of matrix metalloproteinases-2, -9.

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The content of proteins in intrauterine lavage for prognosis of efficiency of the IVF program in chronic endometritis

Cited by 2 publications

References 8 publications

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study

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