The Content of Some Types of Cytokines in Women of Reproductive Age with Exacerbation and Remission of Chronic Herpes Infection

Abstract

There were investigated levels of pro-inflammatory and regulatory cytokines (IL-1β, IL-6 and IFN-γ) in women of reproductive age in periods of exacerbation and remission of chronic infection caused by the herpes simplex virus in purpose to study the pathogenetic features of the course of HSV infection. It is shown that both the period of exacerbation, and the period of clinical remission of chronic herpes infection are characterized by increased production of IFN-γ, IL-1β and IL-6. However, only the mean values of IL-1β were significantly different in periods of exacerbation and remission. Moreover, patients with chronic herpes infection revealed significant heterogeneity of individual values of measured cytokines (IL-1β, IL-6 and IFN-γ), which does not depend on the period of clinical disease.