The Continuum of Dental Caries—Evidence for a Dynamic Disease Process

Featherstone, J.D.B.

doi:10.1177/154405910408301s08

Cited by 556 publications

(475 citation statements)

References 23 publications

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“…22,23 Our BAG-containing adhesives have previously shown calcium ion-release into surrounding solution. 20 This study evaluated the potential use of these novel BAGcontaining orthodontic bonding agents for the prevention of WSLs.…”

Section: Discussionmentioning

confidence: 99%

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Manfred

Covell

Crowe

et al. 2012

The Angle Orthodontist

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Objective: To compare changes in enamel microhardness adjacent to orthodontic brackets after using bonding agents containing various compositions of bioactive glass compared to a traditional resin adhesive following a simulated caries challenge. Materials and Methods: Extracted human third molars (n 5 10 per group) had orthodontic brackets bonded using one of four novel bioactive glass (BAG)-containing orthodontic bonding agents (BAG-Bonds) or commercially available Transbond-XT. The four new adhesives contained BAG in varying percentages incorporated into a traditional resin monomer mixture. Teeth were cycled through low-pH demineralizing and physiologic-pH remineralizing solutions once each day over 14 days. Microhardness was measured on longitudinal sections of the teeth 100, 200, and 300 mm from the bracket edge and beneath the brackets, at depths of 25 to 200 mm from the enamel surface. Normalized hardness values were compared using three-way analysis of variance. Results: Significantly less reduction in enamel microhardness was found with the experimental adhesives at depths of 25 and 50 mm at all distances from the bracket edge. In all groups, there were no significant changes in enamel microhardness past 125-mm depth. Results varied with the different BAG-Bonds, with 81BAG-Bond showing the smallest decrease in enamel microhardness. Conclusions: The BAG-Bonds tested in this study showed a reduction in the amount of superficial enamel softening surrounding orthodontic brackets compared to a traditional bonding agent. The results indicate that clinically, BAG-Bonds may aid in maintaining enamel surface hardness, therefore helping prevent white spot lesions adjacent to orthodontic brackets. (Angle Orthod. 2013;83:97-103.)

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Section: Discussionmentioning

confidence: 99%

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Manfred

Covell

Crowe

et al. 2012

The Angle Orthodontist

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“…Dental caries is a dynamic process 1) , progressing from an initial subclinical lesion, through an early clinical detection phase, to cavitation 2) . The management of dental caries has evolved to early clinical detection of initial lesions and using products inducing remineralization to stop lesion progression and reverse surface demineralization before cavitation occurs 3) .…”

Section: Introductionmentioning

confidence: 99%

Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

et al. 2013

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This study aimed to compare the ability of casein-phosphopeptide amorphous-calcium-phosphate (CPP-ACP) and glass-ionomer (GI) in remineralizing proximal artificial caries lesions (ACLs). Molar enamel-slabs were divided into: original-lesion control, intra-oral controls, and experimental (CPP-ACP or GI) groups. Specimens received ACLs and were bonded on subject maxillary first molars. After 4-weeks, mineral density (MD) was analyzed by μCT. Compared to control, CPP-ACP increased MD at 0-38/68-84 microns and the GI group had an increase at 0-68 microns, with a greater increase in MD compared to the CPP-ACP group from 0-53 microns. The mean percent remineralization (%R) showed differences between the GI, CPP-ACP groups and their paired controls. GI tended to increase remineralization more than CPP-ACP. In conclusion, CPP-ACP and GI demonstrated distinct remineralizing ability. GI induced greater remineralization in the superficial lesion, while CPP-ACP remineralized the lesion body. Their effects on percent remineralization and reducing lesion depth of proximal ACLs were similar.

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“…Various investigators reported that early carious lesions can be re-mineralized from saliva. This process was studied in details in laboratory experiments and in clinical trials (1)(2) .…”

Section: Introductionmentioning

confidence: 99%

Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

2017

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The Continuum of Dental Caries—Evidence for a Dynamic Disease Process

Cited by 556 publications

References 23 publications

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

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