Population issues and population policies have evolved considerably between the 20th and the 21st centuries. In the 1970s, most countries confronted rapid population growth, and this situation was particularly severe in Asia. Today, on the contrary, more than half of the world population is experiencing low fertility and population aging, and several countries with very low fertility are facing the prospect of depopulation. Only one region, i.e., sub-Saharan Africa, still experiences high fertility levels. Similarly, the discussions about whether and how to intervene on population trends have also evolved over the past 70 years. Demographically focused approaches to family planning provision were dominant views in the second half of the 20th century. However, since the International Conference on Population and Development (ICPD) in Cairo in 1994, international population policy paradigms have been reframed to stress the freedom of couples and the reproductive rights of individuals. Consequently, policy interventions have favored client-focused and gender-sensitive approaches. Finally, to help chart the way forward, population policies will need to consider several key elements, broadening from a focus on support for family planning to an array of policy instruments including health, education, and culture, all of which shape future populations. This new policy framework includes the prioritization of interventions, policy consensus building, the selection of priority constituencies, the institutionalization and funding of policies, and the promotion of evidence-based and research-driven policies. In addition, in order to adapt their interventions to local contexts, population policies will need to be holistic, to promote integrated interventions, and to align with international development frameworks.