2021
DOI: 10.1093/burnst/tkaa046
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The contradictory role of androgens in cutaneous and major burn wound healing

Abstract: Wound healing is a complex process involving four overlapping phases: haemostasis, inflammation, cell recruitment and matrix remodeling. In mouse models, surgical, pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-α production and reduce wound re-epithelization and matrix deposition, retarding cutaneous wound healing. Similarly, clinical studies have shown that cutaneous wound healing is slower in men compared to… Show more

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Cited by 8 publications
(2 citation statements)
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“…The difference in gene expression between the wounds of aged and young individuals is regulated almost exclusively by estrogen [ 5 ]. Androgens, however, have a negative effect on wound healing [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…The difference in gene expression between the wounds of aged and young individuals is regulated almost exclusively by estrogen [ 5 ]. Androgens, however, have a negative effect on wound healing [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Sex hormones, including estrogens (estrone and 17 β -estradiol) and androgens and related hormones (testosterone and 5 α -dihydrotestosterone dehydroepiandrosterone), influence the wound healing process [ 7 ]. The difference in gene expression between the wounds of aged and young individuals is regulated almost exclusively by estrogen [ 8 ], whereas androgens negatively affect wound healing [ 9 ].…”
Section: Introductionmentioning
confidence: 99%