The contrasting role of B7-H3

A novel subset of B7-H3+CD14+HLA-DR−/lowmyeloid-derived suppressor cells are associated with progression of human NSCLC

“…16,17 B7-H3 can therefore function as either a T-cell co-stimulator or co-inhibitor depending on the biological context. 18 The exact role of B7-H3 in human cancer remains to be further delineated.…”

B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis

“…Research on the immunologic function of B7-H3 clarified that B7-H3 acts not only as a costimulator but also a coinhibitor in regulating T cell-mediated immune responses. Therefore, it is proposed that there may be both costimulatory and coinhibitory receptors expressed on T cells for B7-H3 (18,27). A recent study identified triggering receptor expressed on myeloid cells-like transcript 2 as a B7-H3 costimulatory receptor (18), but the coinhibitory receptor(s) for B7- H3 have not yet been discovered.…”

“…A recent study identified triggering receptor expressed on myeloid cells-like transcript 2 as a B7-H3 costimulatory receptor (18), but the coinhibitory receptor(s) for B7- H3 have not yet been discovered. It is possible that multiple counterreceptors for B7-H3 may exist on different types of immune cells (18,27). In the current study, we provide the first evidence that a putative receptor for B7-H3 was expressed on peripheral monocytes and peritoneal macrophages, but not on lymphocytes, from septic patients.…”

B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism

“…A recent study identified triggering receptor expressed on myeloid cell-like transcript 2 as a costimulatory receptor for murine B7-H3 (17), but further work on both human and murine B7-H3 did not support this finding (18). Nevertheless, it has been postulated that multiple counterreceptors for B7-H3 may exist on different types of immune cells (17,19).…”