The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Abstract

Diminishing motor function is commonly observed in the elderly population and is associated with a wide range of adverse health consequences. Advanced Glycation End products (AGE’s) may contribute to age-related decline in the function of cells and tissues in normal ageing. Although the negative effect of AGE’s on the biomechanical properties of musculoskeletal tissues and the central nervous system have been previously described, the evidence regarding the effect on motor function is fragmented, and a systematic review on this topic is lacking. Therefore, a systematic review was conducted from a total of eight studies describing AGE’s related to physical functioning, physical performance, and musculoskeletal outcome which reveals a positive association between high AGE’s levels and declined walking abilities, inferior ADL, decreased muscle properties (strength, power and mass) and increased physical frailty. Elevated AGE’s levels might be an indication to initiate (early) treatment such as dietary advice, muscle strengthening exercises, and functional training to maintain physical functions. Further longitudinal observational and controlled trial studies are necessary to investigate a causal relationship, and to what extent, high AGE’s levels are a contributing risk factor and potential biomarker for a decline in motor function as a component of the ageing process.

Association of accumulated advanced glycation end‐products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes

“…Skin AF, representing the accumulation of AGEs, was inversely associated with SMI, grip strength and knee extension strength in an adjusted multivariate logistic regression model in the present study. As reported previously, reduced muscle mass, regarded as the primary phenotype of sarcopenia, is associated with accumulated AGEs in humans as they age. Oxidative stress and inflammatory cytokines are increased by AGEs.…”

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

“…The expression of AGER showed a significant increase in the sperm from D ‐gal‐induced aged rats compared with the control rats. It has been reported that the increased level of AGE is responsible for accelerated aging in D ‐gal‐induced aging model ( Drenth et al, ) . There are now evidence that that D ‐gal treatment also causing the reproductive aging, characterized by decreased sperm count, testis weight, serum testosterone, and LH levels (Ahangarpour et al, ; Liao et al, ; Yang et al, ).…”

Хейропатія У Дітей Із Цукровим Діабетом. Кінезо- І Фізіотерапія

“…Гликозилированные молекулы возбуждают сигналь-ные пути, ассоциированные с мембранными AGE-связывающими рецепторами (AGE-R1, AGE-R2, R3-AGE и RAGE). Активация AGE-связывающих рецепторов индуцирует генерацию активированных кислородсодержащих метаболитов, которые иници-ируют возбуждение провоспалительного сигналь-ного каскада, обусловливая продукцию нескольких цитокинов и факторов роста, вызывающих инду-цированное гипергликемией повреждение клеток и воспаление [10]. Гликозилированные продукты также способствуют накоплению внутриклеточной воды и развитию отека тканей.…”