The contribution of cardiac and extracardiac factors to NT-proBNP concentrations in patients with advanced heart failure before and after left ventricular assist device implantation

Knudsen, Marie Sophie S.; Eismark, Frederik; Goetze, Jens P.; Gustafsson, Finn; Wolsk, Emil

doi:10.1016/j.peptides.2020.170420

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…NT-proBNP has the advantages of long half-life and high stability, and its clinical significance is equivalent to BNP (brain natriuretic peptide). [20][21][22][23][24][25] The level of blood BNP reflects the heart function of the patient. BNP .400 pg/mL is However, in this study, the postoperative NT-proBNP level was significantly lower in the test group than in the control group, demonstrating that the cardiac function of the patients was better in the test group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Lou

Zheng

Xie

et al. 2021

Journal of Cardiovascular Pharmacology

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:We explored the protective effect of spironolactone on cardiac function in the patients undergoing coronary artery bypass grafting (CABG) by determining serum hypoxia-inducible factor-1α (HIF-1α) before and after CABG. We used the propensity score matching method retrospectively to select 174 patients undergoing CABG in our hospital from March 2018 to December 2019. Of the 174 patients, 87 patients taking spironolactone for more than 3 months before CABG were used as a test group and other 87 patients who were not taking spironolactone as a control group. In all patients, serum HIF-1α and troponin I levels were determined before as well as 24 hours and 7 days after CABG, serum N-terminal probrain natriuretic peptide (NT-proBNP) level was determined before as well as 12, 24, and 36 hours after CABG, and electrocardiographic monitoring was performed within 36 hours after CABG. The results indicated that there were no significant differences in the HIF-1α level between the test group and the control group before and 7 days after CABG, but the HIF-1α level was significantly lower in the test group than that in the control group 24 hours after CABG (P < 0.01). The 2 groups were not significantly different in the troponin I level at any time point. There was no significant difference in the serum NT-proBNP level between the test group and the control group before CABG, but NT-proBNP (BNP) levels were all significantly lower in the test group than those in the control group at postoperative 12, 24, and 36 hour time points (all P <0.05). The incidence of postoperative atrial fibrillation was also significantly lower in the test group than that in the control group (P = 0.035). Spironolactone protects cardiac function probably by improving myocardial hypoxia and inhibiting myocardial remodeling.

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Section: Discussionmentioning

confidence: 99%

“…NT-proBNP has the advantages of long half-life and high stability, and its clinical significance is equivalent to BNP (brain natriuretic peptide). 20–25 The level of blood BNP reflects the heart function of the patient. BNP >400 pg/mL is regarded as heart failure in the European Heart Association guidelines.…”

Section: Discussionmentioning

confidence: 99%

Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Lou

Zheng

Xie

et al. 2021

Journal of Cardiovascular Pharmacology

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“…Several studies demonstrated that LVAD implantation reduces circulating levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) [ 18 ], B-type natriuretic peptide (BNP) [ 19 , 20 ] and atrial natriuretic peptide (ANP) [ 19 ]. In a retrospective, single-center study of 63 patients, pulmonary capillary wedge pressure was the only independent predictor of NT-proBNP levels after LVAD implantation [ 21 ]. Furthermore, in animal models of LVAD, the secretion of ANP in response to an increase in central venous pressure was preserved [ 22 ].…”

Section: Neurohormonal Activationmentioning

confidence: 99%

Biomarkers in Patients with Left Ventricular Assist Device: An Insight on Current Evidence

et al. 2022

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Left ventricular assist devices (LVADs) have been representing a cornerstone therapy for patients with end-stage heart failure during the last decades. However, their use induces several pathophysiological modifications which are partially responsible for the complications that typically characterize these patients, such as right ventricular failure, thromboembolic events, as well as bleedings. During the last years, biomarkers involved in the pathways of neurohormonal activation, myocardial injury, adverse remodeling, oxidative stress and systemic inflammation have raised attention. The search and analysis of potential biomarkers in LVAD patients could lead to the identification of a subset of patients with an increased risk of developing these adverse events. This could then promote a closer follow-up as well as therapeutic modifications. Furthermore, it might highlight some new therapeutic pharmacological targets that could lead to improved long-term survival. The aim of this review is to provide current evidence on the role of different biomarkers in patients with LVAD, in particular highlighting their possible implications in clinical practice.

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“…In HD patients, after the intake of active BJ, the nitrate tmax ranged from 45 min to 8 h with a geometric mean value of 2 h. In HV, the nitrate tmax ranged from 45 min to 4 h with a geometric mean value of 1.4 h (data not shown). The release of Pro-BNP is influenced by changes in intracardiac pressure, and its circulating levels are commonly used to assess cardiac function [26,27]. Pro-BNP can also stimulate the release of cGMP via downstream signaling [26].…”

Section: Kinetic Analysismentioning

confidence: 99%

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

et al. 2022

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Nitric oxide (NO) contributes to maintaining normal cardiovascular and renal function. NO is generally formed enzymatically by NO synthase in the vascular endothelium. NO bioactivity can also be attributed to dietary intake of inorganic nitrate, which is abundant in our diet, especially in green leafy vegetables and beets. Ingested nitrate is reduced to nitrite by oral commensal bacteria and further to NO systemically. Previous studies have shown that dialysis, by means of removing nitrate and nitrite from the body, can reduce NO bioactivity. Hence, dietary intervention approaches aimed to boost the nitrate–nitrite–NO pathway may be of benefit in dialysis patients. The purpose of this study was to examine the kinetics of plasma nitrate and nitrite after a single intake of nitrate-rich concentrated beetroot juice (BJ) in adult hemodialysis (HD) patients and in healthy volunteers (HV). Eight HD patients and seven HV participated in this single center, randomized, single-blind, placebo-controlled, crossover study. Each participant received a sequential single administration of active BJ (70 mL 400 mg nitrate) and placebo BJ (70 mL 0 mg nitrate) in a random order separated by a washout period of seven days. For the kinetic analysis, blood samples were collected at different time-points before and up to 44 h after BJ intake. Compared with placebo, active BJ significantly increased plasma nitrate and nitrite levels both in HD patients and HV. The area under the curve and the maximal concentration of plasma nitrate, but not of nitrite, were significantly higher in HD patients as compared with HV. In both groups, active BJ ingestion did not affect blood pressure or plasma potassium levels. Both BJs were well tolerated in all participants with no adverse events reported. Our data provide useful information in planning dietary nitrate supplementation efficacy studies in patients with reduced NO bioactivity.

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The contribution of cardiac and extracardiac factors to NT-proBNP concentrations in patients with advanced heart failure before and after left ventricular assist device implantation

Cited by 5 publications

References 30 publications

Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Biomarkers in Patients with Left Ventricular Assist Device: An Insight on Current Evidence

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

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