The contribution of classical conditioning to tolerance to the antinociceptive effects of ethanol

Tiffany, Stephen T.; McCal, K. J.; Maude-Griffin, Peg M.

doi:10.1007/bf00176489

Cited by 18 publications

(6 citation statements)

References 24 publications

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“…Classical conditioning processes have been implicated in the acquisition of tolerance to certain pharmacological actions of opioids and other centrally-active drugs (Siegel 1973(Siegel , 1978Tiffany et al 1987). This form of learning does not, however, appear to account for the development of "motivational" tolerance since tolerance was observed even when drug injections were conducted in an environment different from that where conditioning sessions occurred.…”

Section: Discussionmentioning

confidence: 99%

Tolerance and selective cross-tolerance to the motivational effects of opioids

et al. 1988

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The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kappa-opioid agonist, U-69593 produced conditioned place aversions. Non-contingent administration of morphine (5.0 mg/kg/12 h) for 4 days prior to conditioning resulted in tolerance to its reinforcing effects, and cross-tolerance to the effects of fentanyl. No cross-tolerance to the motivational effects of the psychostimulant d-amphetamine or the kappa-opioid agonist U-69593 was observed. Chronic administration of U-69593 prior to conditioning produced tolerance to its aversive effects. This treatment did not, however, modify the reinforcement produced by morphine. These data demonstrate that tolerance develops to both the reinforcing and aversive properties of opioids and suggest that differential cross-tolerance may provide a useful method for determining the pharmacological basis underlying drug-induced motivational effects.

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Section: Discussionmentioning

confidence: 99%

Tolerance and selective cross-tolerance to the motivational effects of opioids

et al. 1988

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“…Other studies suggest environment-independent tolerance. For example, rats receiving alcohol injections in a distinct environment developed tolerance to alcohol’s analgesic effects regardless of whether they also received tail-flick tests in the same environment (Tiffany et al, 1987). Learning mechanisms do not appear to influence tolerance development when rats receive alcohol in a liquid diet, however, because comparable tolerance effects were observed regardless of whether repeated pain tests were given during alcohol administration (Gatch and Lal, 1999).…”

Section: Analgesia Hyperalgesia and Alcohol Dependencementioning

confidence: 99%

Alcohol dependence as a chronic pain disorder

Egli¹,

Koob²,

Edwards³

2012

Neuroscience & Biobehavioral Reviews

297

275

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Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia, depression, and PTSD. Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain. In this review, we explore the possible influence of alcohol analgesia and hyperalgesia in promoting alcohol misuse and dependence. We examine evidence that neuroanatomical sites involved in the negative emotional states of alcohol dependence also play an important role in pain transmission and may be functionally altered under chronic pain conditions. We also consider possible genetic links between pain transmission and alcohol dependence. We propose an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates to engender sensory and affective pain states that are integral to alcohol dependence and comorbid conditions such as anxiety, depression, and chronic pain.

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“…In particular, the phenomenon of environment-dependent tolerance has been shown to various ethanol effects such as hypothermic, sedative and antinociceptive effects (Mansfield and Cunningham 1980;Le et al 1987;Siegel 1987;Tiffany et al 1987). Although the biochemical mechanisms underlying such ethanol conditioned effects remain unknown, these must be very rapid to oppose ethanol effects almost immediately after administration.…”

Section: Introductionmentioning

confidence: 96%

Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol

Quertemont¹,

Neuville²,

Witte³

1998

Psychopharmacology

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The excitatory amino acid neurotransmission within the amygdala has been implicated in learning associations between external stimuli and intrinsic reward values such that it may play a key role in conditioned drug effects. In the present studies, the responses of the excitatory amino acids, aspartate and glutamate together with the neuromodulatory sulphonated amino acid taurine, within the basolateral amygdala, to an odor cue repeatedly associated with acute ethanol injections (2g/kg, IP) have been investigated by a microdialysis technique combined with HPLC-EC analysis. After presentation of the ethanol-conditioned stimulus, a single IP saline injection induced an immediate and significant increase in the taurine microdialysate content which could be related to the neuromodulatory action of taurine. Furthermore, when the conditioned stimulus was combined with the ethanol injection (2g/kg, IP), significant increases in both taurine and glutamate microdialysate content were observed and indicated a learned compensatory response to counteract the acute effects of ethanol. These results demonstrate that changes in amygdala extracellular glutamate and taurine concentrations can be conditioned to ethanol-associated stimuli and are therefore probably implicated in the phenomenon of environmental-dependent tolerance to ethanol.

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The contribution of classical conditioning to tolerance to the antinociceptive effects of ethanol

Cited by 18 publications

References 24 publications

Tolerance and selective cross-tolerance to the motivational effects of opioids

Tolerance and selective cross-tolerance to the motivational effects of opioids

Alcohol dependence as a chronic pain disorder

Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol

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