The contribution of different prefrontal cortex regions to recollection and familiarity: a review of fMRI data

Scalici, Francesco; Caltagirone, Carlo; Carlesimo, Giovanni Augusto

doi:10.1016/j.neubiorev.2017.10.017

Cited by 38 publications

(29 citation statements)

References 112 publications

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“…Strongly associated pairs elicited greater recollection-based responding than weakly associated pairs and greater fMRI activation during retrieval in HC and VLPFC, while weakly associated pairs elicited greater activation in DLPFC, which the authors attributed to increased familiaritybased responding. However, contradictory findings have been reported relating increased VLPFC activation, rather than DLPFC, to increases in familiarity-based responding (Scalici et al, 2017;Henson et al, 1999). It is therefore somewhat unclear whether activation in DLPFC or VLPFC will activation will be more correlated with correct rejections of visually integrated pairs.…”

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confidence: 99%

“…For this reason, we predicted that we may observe an overall reduction in DLPFC activation for visually integrated compared to nonintegrated pairs. Activation in DLPFC and VLPFC has also been differentiated based on the dual-process model, albeit with mixed results (Bunge, Burrows, & Wagner, 2004, Scalici et al, 2017Henson et al, 1999). For example, Bunge et al (2004) compared recognition of strongly and weakly associated pairs of novel visual patterns.…”

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Visual integration of objects and scenes increases recollection‐based responding despite differential MTL recruitment in young and older adults

Memel¹,

Ryan

2018

Hippocampus

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Unitization, the process of encoding previously independent units as one coherent representation, improves associative memory in both young and older adults, or in some cases, differentially benefits older adults. Unitization of verbal associative pairs may reduce reliance on the hippocampus (HC) for successful encoding and recognition by shifting to familiarity-based processing mediated by perirhinal cortex (PRC). However, this shift was not observed in a recent study of visual associative memory, with equivalent activation in HC and PRC during encoding of visually integrated (unitized) and nonintegrated object and scene pairs. Furthermore, behavioral findings from this study suggested an increase in recollection rather than familiarity during recognition of visually integrated pairs. The present study extends our previous work by focusing on the influence of visual integration on fMRI activation during associative recognition, rather than encoding and these patterns between young and older adults. In contrast to our findings from encoding, visual integration reduced HC and PRC activation during retrieval of object and scene associative pairs across both age groups. However, visual integration increased the correlation between bilateral HC and left parahippocampal (PHC) activation and behavioral performance among older adults, consistent with an increased reliance on recollection. In contrast, visual integration reduced the correlation between HC activation and behavioral performance in young adults, more consistent with findings from the verbal unitization literature. Taken together, these results suggest that associative memory for visually integrated pairs may involve differential recruitment of medial temporal regions in young and older adults.

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confidence: 99%

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Visual integration of objects and scenes increases recollection‐based responding despite differential MTL recruitment in young and older adults

Memel¹,

Ryan

2018

Hippocampus

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“…However, the ultrahigh magnetic field is harmful to aims to localize brain areas linked to basic functions, such as vision [19], auditory [20,21], language [22,23], moving [24], cognition [25][26][27], etc. The other one is the neurophysiological mechanism of severe brain diseases.…”

Section: Data Acquisitionmentioning

confidence: 99%

A mini review of functional magnetic resonance imaging

Han¹,

Li²

2018

Med Res Innov

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AbstractfMRI, which captures images reflected the hemodynamic changes during the neural activity, shows great potential to uncover the neurophysiological relationship with the brain function and the neuropathological mechanism involved in brain lesions. In this article, an introduction of functional magnetic resonance imaging (fMRI) is presented on its imaging principle, instrumentation and methods, data analysis and current application.

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“…Familiarity memory is a type of recognition memory that is derived from the comparison between incoming information and previously stored representations, but it remains to be established how the brain generates familiarity signals as a function of stored representations and whether these signals are integrated across different brain regions. Indeed, across many functional neuroimaging studies (e.g., Montaldi et al 2006;Skinner and Fernandes 2007;Montaldi 2012, 2014;Scalici et al 2017), familiarity memory has been shown to engage a number of brain regions, which suggests that several interacting processes support familiarity memory and that these processes engage functionally connected brain regions. An important endeavor, therefore, is to characterize the role of the dynamic interactions of networks involved in memory and the integration of familiarity signals.…”

Section: Introductionmentioning

confidence: 99%

Thalamic-medial temporal lobe connectivity underpins familiarity memory

Kafkas

Mayes

Montaldi

2019

Preprint

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The neural basis of memory is highly distributed, but the thalamus is known to play a particularly critical role. However, exactly how the different thalamic nuclei contribute to different kinds of memory is unclear. Moreover, whether thalamic connectivity with the medial temporal lobe (MTL), arguably the most fundamental memory structure, is critical for memory, remains unknown. We explore these questions using an fMRI recognition memory paradigm that taps familiarity and recollection (i.e., the two types of memory that support recognition) for objects, faces and scenes. We show that the mediodorsal thalamus (MDt) plays a materialgeneral role in familiarity, while the anterior thalamus plays a material-general role in recollection. Material-specific regions were found for scene familiarity (ventral posteromedial and pulvinar thalamic nuclei) and face familiarity (left ventrolateral thalamus). Critically, increased functional connectivity between the MDt and the parahippocampal (PHC) and perirhinal cortices (PRC) of the MTL underpinned increases in reported familiarity confidence.These findings suggest that familiarity signals are generated through the dynamic interaction of functionally connected MTL-thalamic structures.

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The contribution of different prefrontal cortex regions to recollection and familiarity: a review of fMRI data

Cited by 38 publications

References 112 publications

Visual integration of objects and scenes increases recollection‐based responding despite differential MTL recruitment in young and older adults

Visual integration of objects and scenes increases recollection‐based responding despite differential MTL recruitment in young and older adults

A mini review of functional magnetic resonance imaging

Thalamic-medial temporal lobe connectivity underpins familiarity memory

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