The Contribution of Endogenous and Exogenous Factors to Male Alopecia

Gatherwright, James; Liu, Mengyuan T.; Amirlak, Bardia; Gliniak, Christy; Totonchi, Ali; Guyuron, Bahman

doi:10.1097/prs.0b013e3182865ca9

Cited by 47 publications

(33 citation statements)

References 39 publications

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“…Consumption of alcohol and smoking was reported to be significantly associated with PMGH in the present study as well as other studies in other parts of the world. [ 10 18 19 20 21 22 23 24 25 ] No significant association was reported between near vision defect or sleep disturbances and PMGH in the present study. The association between sleep disturbances and graying of hair or loss of hair may work indirectly through stress rather than directly.…”

Section: Discussioncontrasting

confidence: 63%

A community based study to estimate prevalence and determine correlates of premature graying of hair among young adults in Srinagar, Uttarakhand, India

2020

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Background: There are several ways by which aging is identified, of which graying of hair is perhaps the most common way. Nowadays, graying of hairs, which was expected to occur after 40s, can be easily observed among younger age group, even before 20s. The present study aims to estimate the prevalence of graying of hairs and its correlates among young adults in Srinagar, Uttarakhand, India. Methodology: A community-based cross-sectional study was conducted among 384 young adults between 15 and 30-year age group in the urban area of Srinagar tehsil of Pauri district. Graying of hair was assessed on the basis of the number of white hairs on examination of scalp. Results: The prevalence of premature graying of hairs (PMGHs) was found to be 27.3%. Binary logistic regression analysis showed that a paternal history of PMGH, history of smoking, maternal history of PMGH, sunlight exposure, and body mass index were significant predictors of PMGH. Limitations: The factors found associated could be better determined through a follow-up study which could not be done in the current study. The present study was carried in a tehsil of one district of Uttarakhand therefore has limited external validity. Conclusion: The present study highlights the importance of maintaining a healthy lifestyle as well as adequate exposure to sunlight in preventing PMGH.

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Section: Discussioncontrasting

confidence: 63%

A community based study to estimate prevalence and determine correlates of premature graying of hair among young adults in Srinagar, Uttarakhand, India

2020

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“…Male pattern baldness is associated with higher levels of dihydrotestosterone and increased expression of androgen receptors . The pathogenesis is generally considered as an androgen‐mediated process in genetically susceptible individuals, and environmental and lifestyle risk factors are likely to be triggers . Male pattern baldness has been associated with increased risk of prostate cancer …”

mentioning

confidence: 99%

“…4 The pathogenesis is generally considered as an androgen-mediated process in genetically susceptible individuals, and environmental and lifestyle risk factors are likely to be triggers. [3][4][5][6][7] Male pattern baldness has been associated with increased risk of prostate cancer. 8,9 A potential androgen basis of melanoma has been proposed to explain the differential gender distribution of melanoma, 10,11 based on which we reported increased risk of melanoma but not keratinocyte carcinoma (KC, also known as non-melanoma skin cancer) associated with personal history of prostate cancer in the Health Professionals' Follow-up Study (HPFS).…”

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confidence: 99%

Male pattern baldness and risk of incident skin cancer in a cohort of men

Cho

Han

et al. 2016

Intl Journal of Cancer

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We examined the association between male-pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals’ Follow-up Study. In 1992, participants reported their status of male-pattern baldness at age 45 years by choosing from five crown-view pictograms based on Norwood’s classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed. We identified 327 melanoma cases, 1324 SCC cases, and 8438 BCC cases during the follow-up. Male-pattern baldness was not significantly associated with risk of incident melanoma, but was significantly associated with increased risk of SCC and BCC. The multivariate-adjusted hazard ratio (HR) (95% confidence interval, CI) for the highest category of baldness (frontal plus severe vertex baldness) was 1.33 (1.06–1.68) for SCC (Ptrend=0.001) and 1.23 (1.12–1.35) for BCC(Ptrend<0.0001), compared with no baldness. Analyses by body sites found significant associations between frontal plus moderate to severe vertex baldness and risk of melanoma (HR=1.83, 95% CI: 1.01–3.34) and SCC (HR=1.30, 95% CI: 1.02–1.66) at head and neck. The associations were particularly stronger for scalp melanoma (HR=7.15, 95% CI: 1.29–39.42) and scalp SCC (HR=7.09, 95% CI: 3.84–13.08), but not for non-scalp head and neck sites. Information on body sites was not available for BCC. In conclusion, male pattern baldness may be associated with increased risk of skin cancer, but the associations may only exist for those occurring at head and neck, particularly at scalp.

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“…In the first one, most probably gene–gene interactions with an epistatic additive effect may predispose for the occurrence of AGA . Of the second group of factors, some characteristics related to the way of life, such as nutrition habits, sports, environmental adverse exposures including smoking, high alcohol consumption, and stress, have been included as risk factors for AGA . Recently, an interesting reported finding by Goodarzi et al .…”

Section: Discussionmentioning

confidence: 99%