The Contribution of Family Planning towards the Prevention of Vertical HIV Transmission in Uganda

Abstract

BackgroundUganda has one of the highest total fertility rates (TFR) worldwide. We compared the effects of antiretroviral (ARV) prophylaxis for the prevention of mother-to-child HIV transmission (PMTCT) to that of existing family planning (FP) use and estimated the burden of pediatric HIV disease due to unwanted fertility.Methodology/Principal FindingsUsing the demographic software Spectrum, a baseline mathematical projection to estimate the current pediatric HIV burden in Uganda was compared to three hypothetical projections: 1) without ARV-PMTCT (to estimate the effect of ARV-PMTCT), 2) without contraception (effect of existing FP use), 3) without unwanted fertility (effect of unmet FP needs). Key input parameters included HIV prevalence, ARV-PMTCT uptake, MTCT probabilities, and TFR. We estimate that in 2007, an estimated 25,000 vertical infections and 17,000 pediatric AIDS deaths occurred (baseline projection). Existing ARV-PMTCT likely averted 8.1% of infections and 8.5% of deaths. FP use likely averted 19.7% of infections and 13.1% of deaths. Unwanted fertility accounted for 21.3% of infections and 13.4% of deaths. During 2008–2012, an estimated 131,000 vertical infections and 71,000 pediatric AIDS deaths will occur. The projected scale up of ARV-PMTCT (from 39%–57%) may avert 18.1% of infections and 24.5% of deaths. Projected FP use may avert 21.6% of infections and 18.5% of deaths. Unwanted fertility will account for 24.5% of infections and 19.8% of deaths.ConclusionsExisting FP use contributes as much or more than ARV-PMTCT in mitigating pediatric HIV in Uganda. Expanding FP services can substantially contribute towards PMTCT.

Demand for Modern Family Planning among Married Women Living with HIV in Western Ethiopia

“…This may be due to perceived fear of MTCT among HIV positive women [18], [22]. Satisfying demand for modern family planning improves the prospects of mothers' survival.…”

Contraceptive Practices and Fertility Desires Among HIV-Infected and Uninfected Women in Kenya

“…For HIV-infected women who do not wish to become pregnant, FP offers the added benefit of PMTCT and, by extension, reduces the number of children needing HIV prophylaxis, treatment, care, and support. 15 We recommend that greater programmatic emphasis should be placed on FP services for all women.…”

Evaluating the cost-effectiveness of combination antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Uganda

“…19 Untreated HIV-positive neonates were assumed to live a mean of 2 years, based on pooled mortality data from several African studies. 20 For women with CD4+ cell counts of < 350 cells/mm 3 at the time of ART initiation, life expectancy was assumed to be 19.3 years, based on survival estimates derived from an African model.…”