“…Above mentioned findings were confirmed and explored in more detail in 2018 in another study, which aimed at a gender effect in particular symptomatic domains of HD and their contribution to functional abilities and quality of life ( 44 ). The clinical picture of HD is formed by three major symptomatic domains, namely motor symptoms (e.g., clumsiness, chorea, dystonia), cognitive impairment (subcortical dementia), and behavioral disturbances (e.g., depression, apathy, irritability, and aggression) ( 22 ).…”