2018
DOI: 10.1016/j.parkreldis.2018.01.006
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The contribution of gender differences in motor, behavioral and cognitive features to functional capacity, independence and quality of life in patients with Huntington's disease

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Cited by 51 publications
(29 citation statements)
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“…Above mentioned findings were confirmed and explored in more detail in 2018 in another study, which aimed at a gender effect in particular symptomatic domains of HD and their contribution to functional abilities and quality of life ( 44 ). The clinical picture of HD is formed by three major symptomatic domains, namely motor symptoms (e.g., clumsiness, chorea, dystonia), cognitive impairment (subcortical dementia), and behavioral disturbances (e.g., depression, apathy, irritability, and aggression) ( 22 ).…”
Section: Sex Plays a Rolementioning
confidence: 75%
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“…Above mentioned findings were confirmed and explored in more detail in 2018 in another study, which aimed at a gender effect in particular symptomatic domains of HD and their contribution to functional abilities and quality of life ( 44 ). The clinical picture of HD is formed by three major symptomatic domains, namely motor symptoms (e.g., clumsiness, chorea, dystonia), cognitive impairment (subcortical dementia), and behavioral disturbances (e.g., depression, apathy, irritability, and aggression) ( 22 ).…”
Section: Sex Plays a Rolementioning
confidence: 75%
“…The limitation factor of the finding ( 39 , 44 ) is a lack of inclusion of two important, however difficult to be assessed variables, namely concomitant disorders and medications. There is still a question whether differences in these two variables could explain gender differences reported so far ( 39 , 44 ). Depression was considered as a confounder in both studies but did not explain differences in HD progression rate between genders.…”
Section: Discussionmentioning
confidence: 99%
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“…In our study, the deepening of disability as the disease progressed was significantly associated with a decrease in quality of life. An increase in functional impairment significantly correlates with a decrease in QoL [8,46]. As for the group of people with HD studied by us, the quality of life of the subjects measured by the H-QoL-I was at a medium level (Mean = 52.69; SD = 26.67), with the highest component in the social domain (Mean = 69.86; SD = 26.85) and the lowest in the psychological domain (Mean = 42.39; SD = 28.12).…”
Section: Discussionmentioning
confidence: 99%
“…Movement disorders in patients with HD significantly affect and differentiate their level of functioning [2], as motor and cognitive performance deteriorate over time. The decrease in functional performance significantly correlates with a decrease in quality of life (QoL) [8]. Studying the functional state and level of disability as well as the quality of life of patients with HD is recommended in order to assess the progress of the disease, implement interventions, monitor the patient's condition, and optimize care [6].…”
Section: Introductionmentioning
confidence: 99%