The contribution of HLA-Class II antigens in humoral non-response and delayed response to HBsAg vaccination

Vidan-Jeras, B.; Brinovec, Vlado; Jurca, Bojan; Stezinar, Snežna Levičnik; Jeras, Matjaž; Bohinjec, M.

doi:10.1007/s004240000059

Cited by 11 publications

(5 citation statements)

References 2 publications

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“…A number of studies have linked HLA class I, II and III variation to non-response or low response to hepatitis B vaccine [18] – [28] . The most consistent findings regarding high response are associations with DRB1*01 (DR1), DRB1*11 (DR5), DRB1*15 (DR2), DQB1*0501, DPB1*0401; non-response has been shown repeatedly to correlate with DRB1*03, DRB1*07, DQB1*02, DPB1*1101 [29] , [30] .…”

Section: Introductionmentioning

confidence: 99%

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

et al. 2008

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BackgroundVaccination against hepatitis B virus infection (HBV) is safe and effective; however, vaccine-induced antibody level wanes over time. Peak vaccine-induced anti-HBs level is directly related to antibody decay, as well as risk of infection and persistent carriage despite vaccination. We investigated the role of host genetic factors in long-term immunity against HBV infection based on peak anti-HBs level and seroconversion to anti-HBc.MethodsWe analyzed 715 SNP across 133 candidate genes in 662 infant vaccinees from The Gambia, assessing peak vaccine-induced anti-HBs level and core antibody (anti-HBc) status, whilst adjusting for covariates. A replication study comprised 43 SNPs in a further 393 individuals.ResultsIn our initial screen we found variation in IFNG, MAPK8, and IL10RA to affect peak anti-HBs level (GMTratio of <0.6 or >1.5 and P≤0.001) and lesser associations in other genes. Odds of core-conversion was associated with variation in CD163. A coding change in ITGAL (R719V) with likely functional relevance showed evidence of association with increased peak anti-HBs level in both screens (1st screen: s595_22 GMTratio 1.71, P = 0.013; 2nd screen: s595_22 GMTratio 2.15, P = 0.011).ConclusionThis is to our knowledge the largest study to date assessing genetic determinants of HBV vaccine-induced immunity. We report on associations with anti-HBs level, which is directly related to durability of antibody level and predictive of vaccine efficacy long-term. A coding change in ITGAL, which plays a central role in immune cell interaction, was shown to exert beneficial effects on induction of peak antibody level in response to HBV vaccination. Variation in this gene does not appear to have been studied in relation to immune responses to viral or vaccine challenges previously. Our findings suggest that genetic variation in loci other than the HLA region affect immunity induced by HBV vaccination.

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Section: Introductionmentioning

confidence: 99%

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

et al. 2008

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“…The strength of our findings was that they were not biased by age, sex, disease and treatment duration and RF/anti CCP seropositivity as p values were corrected for these factors. In addition, our study was not biased by genetic heterogeneity since all the patients were recruited in a geographic area with an ethnically homogeneous population and the treatment and the follow up is centralized for all RA patients [39].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms Modifying Oxidative Stress Are Associated with Disease Activity in Rheumatoid Arthritis Patients

et al. 2009

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Abstract.Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT)n polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 joint count (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values and a higher probability for low disease activity than non-carriers (p = 0.003, OR = 3.585, 95% CI = 1.538-8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA.

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“…Also, all the analyses were carried out in the same laboratory, so there were no deviations of laboratory parameters due to potential differences in analytical procedures. Furthermore, all the patients and controls came from an ethnically homogeneous Slovenian population, so there was no bias due to genetic heterogeneity [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

SLC6A45HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome

Šenk

Goričar

Kravos

et al. 2018

International Journal of Endocrinology

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Purpose To investigate in a pilot study of genetic polymorphisms in serotonin system influencing basal- and glucose-stimulated insulin secretion in women with polycystic ovary syndrome (PCOS). Methods A cross-sectional study included 65 female patients with PCOS followed up at the endocrine outpatient clinic of the University Medical Center Ljubljana and a control group of 94 young healthy female blood donors. Oral glucose tolerance test was performed only in PCOS patients and basal- and glucose-stimulated blood glucose and insulin levels were measured. All the subjects were genotyped for 5HTR1A rs6295, 5HTR1B rs13212041, and SLC6A4 5HTTLPR polymorphisms in the serotonin system. Results Genotype distributions were in accordance with the Hardy-Weinberg equilibrium (HWE), except for 5HTR1A rs6295 in healthy controls and 5HTR1B rs13212041 in PCOS patients that were not consistent with HWE. SLC6A4 5HTTLPR polymorphism was significantly associated with insulin secretion (p = 0.030) and with the area under the curve of insulin blood levels during OGTT (p = 0.021). None of the investigated polymorphisms was significantly associated with basal- or glucose-stimulated blood glucose levels at any point in time during OGTT or with the basal insulin concentration. Conclusions Serotonin system may play a role in glucose-stimulated insulin secretion in patients with insulin resistance (IR) and decreased insulin sensitivity. Further studies are needed to conclude whether the observed effect is characteristic for PCOS-related metabolic disturbances or for the identified mutation in different high metabolic risk populations.

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The contribution of HLA-Class II antigens in humoral non-response and delayed response to HBsAg vaccination

Cited by 11 publications

References 2 publications

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

Genetic Polymorphisms Modifying Oxidative Stress Are Associated with Disease Activity in Rheumatoid Arthritis Patients

SLC6A45HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome

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