The purpose of the article is to analyze the specific modern features of the transformation of the knowledge component of TNC. The methodological basis of the articles can be described by the variety of methods, such as comparative and synthesis methods, methods of abstract logical evaluation, system approaches, methods of detailing, groupings and generalizations, logic analysis, paired and multiple correlation techniques. The scientific-theoretical principles of building up the intellectual capital of TNCs, which are expressed in the concentration of technological priorities, the development and implementation of innovations, technologies, business models, and the formation of a holistic knowledge management system, are analyzed. Levels of knowledge utilization of TNCs are determined. The strategic vision of the TNC in the paradigm of the knowledge economy has been developed. The substantiated role of the intellectual component in the process of forming the competitive potential of TNCs, which is based on the identification of the latest features of corporate knowledge, which serve as a determining factor of economic growth, being in various forms of its manifestation: as a resource embodied (materialized) in technologies and equipment; as a constituent element of human capital, which interacts with the subjects' existing skills, experience, ability to reproduce and update knowledge, use it in their activities; as newly created knowledge, which is the result of research, development and other types of scientific activity of a fundamental and applied nature; as new goods that further contribute to the formation of new markets. The main theoretical and methodological provisions of the development of the knowledge component are formulated, the determinants of the formation of a new knowledge paradigm of TNCs are determined, and recommendations are provided for the strategic development of TNCs in the knowledge economy can be used by scientists, teachers, students, and economists who deal with the issues of the influence of the knowledge component on the development of TNCs.