The Contribution of Malodour in Quality of Life of Patients With Hidradenitis Suppurativa

Alavi, Afsáneh; Farzanfar, Delaram; Lee, Rosa Kyuwon; Almutairi, Dalal

doi:10.1177/1203475417745826

Cited by 43 publications

(52 citation statements)

References 18 publications

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“…Amino acid metabolism may impact body odor and skin pH. Malodor significantly impairs the quality of life in HS patients (Alavi et al 2018). The breakdown of isoleucine to isovaleric acid contributes to "sour" odor (Lam et al 2018), and we identified altered isoleucine biosynthesis and degradation pathways in HS skin.…”

Section: Discussionmentioning

confidence: 71%

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

Schneider

Cook

Zhan

et al. 2019

Preprint

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Hidradenitis Suppurativa (HS) is a chronic, scarring, inflammatory skin disease affecting hair follicles in axillae, inguinal, and anogenital regions. Dysbiosis in HS patients compared to healthy subjects is documented. However, whether dysbiosis is specific to particular body sites or skin niches is unknown. We investigated the follicular and skin surface microbiome of the axilla and groin of HS patients (n=11) and healthy individuals (n=10) using 16S rRNA gene sequencing (V3-V4). We sampled non-lesional (HSN) and lesional skin (HSL) of HS patients. β-diversity was significantly decreased (p<0.05) in HSN and HSL skin compared to normal skin with loss of body site and skin niche heterogeneity in HS samples. The relative bacterial abundance of specific microbes was also significantly different between normal and HSN (15 genera) or HSL (21 genera) skin. Smoking and alcohol use influenced the β-diversity (p<0.08) in HS skin. We investigated metabolic profiles of bacterial communities in HS and normal skin using a computational approach.Metabolism, Genetic Information Processing, andEnvironmental Information Processingwere significantly different between normal and HS samples. Altered metabolic pathways associated with dysbiosis of HS skin suggest mechanisms underlying the disease pathology and information about treatment with drugs targeting those pathways.

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Section: Discussionmentioning

confidence: 71%

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

Schneider

Cook

Zhan

et al. 2019

Preprint

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“…Profound impact on the HRQoL of Irish HS patients was reported, including diminished work productivity and various psychological comorbidities . The severity of odour in HS patients was associated with total Skindex‐29 scores but not with DLQI scores . In an international study of the QoL impact of treatment (the last DLQI item), over half of HS patients reported problems .…”

Section: Resultsmentioning

confidence: 99%

“…83 The severity of odour in HS patients was associated with total Skindex-29 scores but not with DLQI scores. 84 In an international study of the QoL impact of treatment (the last DLQI item), over half of HS patients reported problems. 85 The relationship of serum zinc levels with QoL and disease severity in HS was studied: low zinc levels were associated with DLQI !…”

Section: Validation Of Hs-specific Qol Instrumentsmentioning

confidence: 99%

Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient‐Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

Chernyshov

Zouboulis

Tómas-Aragonés

et al. 2019

Acad Dermatol Venereol

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This paper is organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Quality of Life (QoL) and Patient‐Oriented Outcomes and the EADV TF on acne, rosacea and hidradenitis suppurativa (ARHS). The purpose of this paper was to present current knowledge about QoL assessment in HS, including data on HS‐specific health‐related (HR) QoL instruments and HRQoL changes in clinical trials, and to make practical recommendations concerning the assessment of QoL in people with HS. HS results in significant quimp that is higher than in most other chronic skin diseases. HS impact in published studies was assessed predominantly (84% of studies) by the Dermatology Life Quality Index (DLQI). There is a lack of high‐quality clinical trials in HS patients where HRQoL instruments have been used as outcome measures. One double‐blind randomized placebo‐controlled trial on infliximab with low number of participants reported significantly better HRQoL improvement in the treatment group than in the placebo group. Well‐designed clinical studies in HS patients to compare different treatment methods, including surgical methods and assessing long‐term effects, are needed. Because of lack of sufficient validation, the Task Forces are not at present able to recommend existing HS‐specific HRQoL instruments for use in clinical studies. The EADV TFs recommend the dermatology‐specific DLQI questionnaire for use in HS patients. The EADV TFs encourage the further development, validation and use of other HS‐specific, dermatology‐specific and generic instruments but such use should be based on the principles presented in the previous publications of the EADV TF on QoL and Patient‐Oriented Outcomes.

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“…Pain and discomfort had the most significant impact on the index. Vinding et al (16) found a mean EQ-5D index of 0.82 (95% confidence interval (CI): 0.74--0.90) and a mean VAS score of 79.56 (95% CI: 72.89-86.22). It is speculated that the participants had less severe disease than those in the present hospital-based study because they were drawn from the general population.…”

Section: Hospital-based Studies Of Hr-qol In Hidradenitismentioning

confidence: 99%

“…There was no difference in mean DLQI scores for the low-vs highodour groups, but patients with high odour had a greater quality of life impairment as measured by the Skindex tool (t = −4.19, df = 43, P < 0.0001, mean difference = −18.87). 16 In an interesting probe of the impact of HS on body image researchers in Germany using the Frankfurt Body Concept Scale found that HS significantly reduced body image (mean FKKS score, 234.2 [5.4] in patients and 276.9 [5.7] in controls; P < 0.001), even when controlled for BMI. 17 A correlation was found for the extent of body image disruption and BMI (r = −0.589; P < 0.001), HADSdepression score (r = −0.619; P < 0.001), and HADSanxiety score (r = −0.340; P = 0.03).…”

Section: Hospital-based Studies Of Hr-qol In Hidradenitismentioning

confidence: 99%

<p>An Update on Health-Related Quality of Life and Patient-Reported Outcomes in Hidradenitis Suppurativa</p>

Mahon¹,

Kirthi²,

Byrne³

et al. 2020

PROM

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Hidradenitis suppurativa is a common inflammatory skin condition which causes recurrent abscesses, sinuses and scarring in the axillae, groin and inframammary areas. As well as causing significant physical distress due to pain and discharge, the condition impacts psychological well-being with markedly impaired quality of life. Patients suffer pain, embarrassment and psychological distress with impairment of their work and intimate relationships marking it as one of the most distressing dermatological conditions. Numerous studies have documented markers of psychological distress encompassing the physical effects such as pain and itch, affects on mood and impaired function.

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The Contribution of Malodour in Quality of Life of Patients With Hidradenitis Suppurativa

Cited by 43 publications

References 18 publications

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient‐Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

<p>An Update on Health-Related Quality of Life and Patient-Reported Outcomes in Hidradenitis Suppurativa</p>

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