The Contribution of Mitochondria to Sensory Processing and Pain

Flatters, Sarah J.L.

doi:10.1016/bs.pmbts.2014.12.004

Cited by 93 publications

(59 citation statements)

References 98 publications

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“…Although important work has begun in the area of CIBP, 39,102,103,105 CIPN, 66,74,97,98 and PCP, 55,93 additional research is needed to elucidate the neurobiological factors responsible for cancer pain. An exciting line of investigation is the interactions among the cancer microenvironment, the primary afferent nociceptor, and the immune system.…”

Section: Discussionmentioning

confidence: 99%

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

Paice¹,

Mulvey

Bennett

et al. 2017

The Journal of Pain

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Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system. After the establishment of these characteristics, a working group consisting of clinicians and clinical and basic scientists with expertise in cancer and cancer-related pain was convened to generate core diagnostic criteria for an illustrative sample of 3 chronic pain syndromes associated with cancer (ie, bone pain and pancreatic cancer pain as models of pain related to a tumor) or its treatment (ie, chemotherapy-induced peripheral neuropathy). A systematic review and synthesis was conducted to provide evidence for the dimensions that comprise this cancer pain taxonomy. Future efforts will subject these diagnostic categories and criteria to systematic empirical evaluation of their feasibility, reliability, and validity and extension to other cancer-related pain syndromes.

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Section: Discussionmentioning

confidence: 99%

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

Paice¹,

Mulvey

Bennett

et al. 2017

The Journal of Pain

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“…The primary purposes of this review are to summarize the impact of diabetes on this critical signaling axis and relate to axonal degeneration in diabetes. For background information, the reader is directed toward recent exhaustive reviews covering broad aspects of the putative involvement of mitochondrial dysfunction underpinning a range of neuropathic diseases [28][29][30] and its role in development of diabetic complications [31].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction in Diabetic Neuropathy: a Series of Unfortunate Metabolic Events

Fernyhough

2015

Curr Diab Rep

123

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Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous system where mitochondrial dysfunction has been implicated as an etiological factor. Diabetes (type 1 or type 2) invokes an elevation of intracellular glucose concentration simultaneously with impaired growth factor support by insulin, and this dual alteration triggers a maladaptation in metabolism of adult sensory neurons. The energy sensing pathway comprising the AMP-activated protein kinase (AMPK)/sirtuin (SIRT)/peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) signaling axis is the target of these damaging changes in nutrient levels, e.g., induction of nutrient stress, and loss of insulin-dependent growth factor support and instigates an aberrant metabolic phenotype characterized by a suppression of mitochondrial oxidative phosphorylation and shift to anaerobic glycolysis. There is discussion of how this loss of mitochondrial function and transition to overreliance on glycolysis contributes to the diminishment of collateral sprouting and axon regeneration in diabetic neuropathy in the context of the highly energy-consuming nerve growth cone.

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“…This explains the predominance of sensory manifestation is patients affected by neuropathy 12,13 . A common finding in nervous conduction studies is a sensory axonal injury with decreased action potentials amplitude, which may result from more complex cell changes resulting from mitochondrial alterations 14 , interference with microtubules; qualitative neuronal membrane changes, oxidative stress 15 and neuronal apoptosis 16 .…”

Section: Pathophysiologymentioning

confidence: 99%