The contribution of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched casecontrol study

Zvizdić, Zlatan; Milišić, Emir; Jonuzi, Asmir; Terzic, Sabina; Zvizdić, Denisa

doi:10.24953/turkjped.2019.04.007

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The clinical characteristics of the cohort were previously reported [4]. The study was conducted in accordance with the Declaration of Helsinki 1964 and the local institutional review board approved the study (Approval number: 0305-11118/2010) [4].…”

Section: Methodsmentioning

confidence: 99%

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

et al. 2020

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Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial to reduce the morbidity and mortality of the affected infants. The aim of this study was to evaluate the diagnostic yield of bowel dilatation on plane abdominal radiography (AR) in the early diagnosis and NEC severity in preterm infants. Methods: We retrospectively reviewed initial ARs of 50 preterm infants with NEC ≥ stage II admitted to the neonatal intensive care unit (NICU) in a tertiary-care hospital. The largest bowel loops diameters (AD), the latero-lateral diameters of the peduncle of the first lumbar vertebra (L1), and the distance of the upper edge of the first lumbar vertebra and the lower edge of the second one, including the disc space (L1–L2), were measured. All anteroposterior ARs were done in a supine projection on the day of onset of the initial symptoms of NEC. Results: Preterm infants with surgical NEC showed a statistically significant increase in the AD/L1 ratio (p < 0.001) and AD/L1-L2 ratio (p < 0.001) compared with preterm infants with medical NEC. We found no significant association between the site of the most distended bowel loop and the severity of NEC (p > 0.05). Conclusion: Bowel loop distension on initial AR may serve as an additional diagnostic tool in the early diagnosis and severity of stages II/III NEC. Further prospective clinical studies should validate the results from this study.

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Section: Methodsmentioning

confidence: 99%

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

et al. 2020

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“…Several other risk factors for the NEC development in the neonatal intensive care units (NICU) have been reported including the use of invasive respiratory support (20), administration of morphine sulfate (21), the presence of circulation impairment requiring inotropic drug administration (22), erythrocyte transfusions (23), and nosocomial infections (24).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study

Zvizdić

Milišić

Jonuzi

et al. 2021

Acta Med. (Hradec Kralove, Czech Repub.)

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Introduction: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world. Materials and Methods: One hundred twenty-two preterm infants were enrolled in the study. The multivariate logistic regression model was used to identify potential postnatal risk factors associated with NEC. Results: Preterm infants (n = 51) with total NEC, medical NEC, and surgical NEC had the highest rate of receiving ranitidine compared with controls (n = 71) (39.2%, 19.6%, and 47.6%, p < 0.05). Logistic regression analysis revealed that ranitidine use and nosocomial infections were significantly associated with NEC development (odds ratios 1.55 and 3.3). Conclusions: We confirm that ranitidine administration was associated with an increased risk of NEC in preterm infants. H2-blockers use should be only administered in very strictly selected cases after careful consideration of the risk-benefit ratio.

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Opioids for procedural pain in neonates

Kinoshita

Olsson

Borys

et al. 2021

Cochrane Database of Systematic Reviews

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The contribution of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched casecontrol study

Abstract: of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched case-control study.

Cited by 5 publications

References 21 publications

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study

Opioids for procedural pain in neonates

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