The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Yayehrad, Ashagrachew Tewabe; Marew, Tesfa; Birhanu, Gebremariam

doi:10.1002/prp2.849

Cited by 16 publications

(17 citation statements)

References 99 publications

(217 reference statements)

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“…Instead, nano-strategies for combating multidrug resistant bacteria have emerged as a viable means to overcome the aforementioned problems associated with bacterial resistance [11][12][13]. Recent advances in nanotechnology provide new opportunities for the development of innovative delivery vehicles based on unique types of nanoparticulate systems with varying sizes and shapes and malleable antibacterial activities.…”

Section: Introductionmentioning

confidence: 99%

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity

et al. 2022

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Cefotaxime (CTX) is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram negative and Gram positive bacteria. However, like other third-generation cephalosporin antibiotics, its efficacy is declining due to the increased prevalence of multidrug-resistant (MDR) pathogens. Recent advances in nanotechnology have been projected as a practical approach to combat MDR microorganisms. Therefore, in the current study, gold nanoparticles (AuNPs) were prepared using cefotaxime sodium, which acted as a reducing and capping agent, besides having well-established antibacterial activity. The synthesized cefotaxime-loaded gold nanoparticles (C-AuNPs) were characterized by UV-Visible spectroscopy, FTIR, TEM and DLS. In addition, the in vitro antibacterial activity of C-AuNPs was assessed against both Gram-positive and Gram-negative bacteria. UV-Visible spectroscopy verified the formation of C-AuNPs, while TEM and DLS verified their nano-size. In addition, CTX loading onto AuNPs was confirmed by FTIR. Furthermore, the colloidal stability of the synthesized C-AuNPs was ascribed to the higher net negative surface charge of C-AuNPs. Most importantly, the synthesized C-AuNPs showed superior antibacterial activity and lower minimum inhibitory concentration (MIC) values against Gram-negative (Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria, compared with pure CTX. Collectively, CTX was successfully adopted, as reducing and capping agent, to synthesize stable, nano-sized spherical C-AuNPs. Furthermore, loading CTX onto AuNPs could efficiently restore and/or boost the antibacterial activity of CTX against resistant Gram-negative and Gram-positive bacteria.

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Section: Introductionmentioning

confidence: 99%

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity

et al. 2022

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“…CFX was initially used for severe or multi-drug resistant infections (e.g., meningitis, lower respiratory tract infections, community and hospital-acquired pneumonia, acute exacerbations of chronic bronchitis, intra-abdominal infections, urinary tract infections including pyelonephritis, bacterial endocarditis, and infections of bones and joints) [7]. Since then, CFX has also undergone resistance development, including in ESBL-producing E. coli, as recently reviewed [8], in which the production of ESBL was identified as a major resistance mechanism [9].…”

Section: Introductionmentioning

confidence: 99%

“…Another way to tackle antibiotic resistance is to improve antibiotic delivery systems in order to reduce the amount and frequency of antibiotic doses or implement targeting. Among current drug delivery systems, nano-carriers have been shown to be highly potent [8,[18][19][20][21][22]. Antibiotic nanoparticles (NP) reportedly [23,24] enhanced antibiotic effects via the formation of a local reservoir close to the bacterial cell wall [25].…”

Section: Introductionmentioning

confidence: 99%

Oligonucleotide Solid Nucleolipid Nanoparticles against Antibiotic Resistance of ESBL-Producing Bacteria

et al. 2022

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Antibiotic resistance has become a major issue in the global healthcare system, notably in the case of Gram-negative bacteria. Recent advances in technology with oligonucleotides have an enormous potential for tackling this problem, providing their efficient intrabacterial delivery. The current work aimed to apply this strategy by using a novel nanoformulation consisting of DOTAU, a nucleolipid carrier, in an attempt to simultaneously deliver antibiotic and anti-resistance oligonucleotides. Ceftriaxone, a third-generation cephalosporin, was formulated with DOTAU to form an ion pair, and was then nanoprecipitated. The obtained solid nanocapsules were characterized using FT-IR, XRD, HPLC, TEM and DLS techniques and further functionalized by the anti-resistance ONα sequence. To obtain an optimal anti-resistance activity and encapsulation yield, both the formulation protocol and the concentration of ONα were optimized. As a result, monodispersed negatively charged nanoparticles of CFX–DOTAU-ONα with a molar ratio of 10:24:1 were obtained. The minimum inhibitory concentration of these nanoparticles on the resistant Escherichia coli strain was significantly reduced (by 75%) in comparison with that of non-vectorized ONα. All aforementioned results reveal that our nanoformulation can be considered as an efficient and relevant strategy for oligonucleotide intrabacterial delivery in the fight against antibiotic resistance.

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“…Polymer nanocomposites were prepared by solvent casting technique [ 24 , 25 ]. First, aqueous solutions of SA and PVA were prepared by dissolving them separately in beakers filled with 50 mL of distilled water; glycerol was used as a plasticizer.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and In Vitro/Ex Vivo Characterizations of Ceftriaxone-Loaded Sodium Alginate/poly(vinyl alcohol) Clay Reinforced Nanocomposites: Possible Applications in Wound Healing

et al. 2022

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(1) Background: Nanocomposite films are widely applied in the pharmaceutical industry (e.g., nanodrug delivery systems—NDDS). Indeed, these nanomaterials can be produced at a large industrial scale and display valuable properties (e.g., antibacterial, renewability, biodegradability, bioavailability, safety, tissue-specific targeting, and biocompatibility), which can enhance the activity of conventional marketed drugs. (2) Aim: To fabricate and investigate the in vitro properties of the antibiotic ceftriaxone sodium (CTX) once encapsulated into sodium alginate (SA)/poly(vinyl alcohol)PVA-clay reinforced nanocomposite films. (3) Methods: Different ratios of the polymers (i.e., SA, PVA) and CTX drug were used for the synthesis of nanocomposite films by solvent casting technique. Montmorillonite (MMT), modified organically, was added as a nanofiller to increase their thermal and mechanical strength. The prepared samples were physically characterized by thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electronic microscopy (SEM), and energy-dispersive X-ray analysis (EDX). The physicochemical behavior (i.e., swelling, erosion, dissolution/drug release behavior and rat skin permeation) was also assessed. Comparisons were made with the currently marketed free CTX dosage form. (4) Results: TGA of the nanoformulation showed increased thermostability. XRD revealed its semi-crystalline nature. SEM depicted a homogeneous drug-loaded SA/PVA nanocomposite with an average size ranging between 300 and 500 nm. EDX confirmed the elemental composition and uniform distribution of mixing components. The water entrapment efficiency study showed that the highest swelling and erosion ratio is encountered with the nanoformulations S100(3) and S100D15(3). Ex vivo permeation revealed a bi-step discharge mode with an early burst liberation chased by continued drug discharge of devised nanoparticles (NPs). The dissolution studies of the drug-loaded polymer nanocomposites elicited sustained pH-dependent drug release. The cumulative drug release was the highest (90.93%) with S100D15(3). (5) Conclusion: S100D15(3) was the finest formulation. To the best of our knowledge, we also pioneered the use of solvent casting for the preparation of such nanoformulations. Polymers and reinforcing agent, concentrations and pH were rate-deterring features for the preparation of the optimized formulation. Thus, CTX-loaded SA/PVA-MMT reinforced nanocomposite appeared as a promising nanodrug delivery system (NDDS) based on its in vitro physicochemical properties.

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The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Cited by 16 publications

References 99 publications

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity

Oligonucleotide Solid Nucleolipid Nanoparticles against Antibiotic Resistance of ESBL-Producing Bacteria

Synthesis and In Vitro/Ex Vivo Characterizations of Ceftriaxone-Loaded Sodium Alginate/poly(vinyl alcohol) Clay Reinforced Nanocomposites: Possible Applications in Wound Healing

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