The goal of this article is to propose a cross-perspective around Collaborative Robotics—seen as a remarkable example of technologies 4.0 in an industrial context—by calling on sociology, activity-centred ergonomics, engineering, and robotics expertises. The development of this cross-perspective is thought to be a key issue to improve the design of work organisation for the Industry 4.0. After a socio-historical review of promises of Collaborative Robotics, the interdisciplinary approach developed and applied in a French Small & Medium Enterprise (SME) is presented. In this case study, two work situations are focused on in an interdisciplinary perspective: on the one hand, the one of operators whose professional gestures are intended to be supported by collaborative robots, and on the other the one of managers and executives as responsible for socio-technical changes. Our results reveal the technical and socio-organisational challenges faced by SMEs beyond the introduction of given technologies: analysing the relevance and feasibility of cobotisation projects with regard to the complexity of professional gestures and preserving the quality of work and performance under a continuous pressure to change (organisations, technologies). These findings support discussions of promises of collaborative robotics, and more generally Industry 4.0, regarding effective worker/technology collaboration and the possibility of “healthy” and performant work; they reiterate requirements for work-centred and participatory design, for reconnection in a sensory experience in a more and more digitalized work and open ways for more interdisciplinary approaches.