The contribution of phenolics to the anti-inflammatory potential of the extract from Bolivian coriander (Porophyllum ruderale subsp. ruderale)

Nephroprotective Activity of Papaloquelite (Porophyllum ruderale) in Thioacetamide-Induced Injury Model

“…These results are in accordance with other studies where authors observed that methanolic extracts of other Porophyllum species are not cytotoxic in the mouse macrophage cell line RAW264.7 at concentrations ranging from 0.06 to 200 mg/mL [36,37]. In addition, Pawłowska et al [30] found that an aqueous extract of aerial parts of Porophyllum ruderale at a concentration range of 5 to 100 µg/mL does not affect the viability of human neutrophil cells.…”

“…The most abundant compounds were 2-O-caffeoyl-2C-methyl-D-erythronic acid, 5-O-caffeoylquinic acid, quercetin-3-O-β-D-glucuronide and 3-O-caffeoyl-2C-methyl-D-erythronic acid (152.59, 143.77, 65.54 and 54.70 mg/g extract, respectively). Additionally, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-D-glucopyranoside, 4-Ocaffeoylquinic acid and 3-O-caffeoyl quinic acid were identified too [30]. In another study performed on P. ruderale from Brazil, authors found chlorogenic acid and quercetin-3-O-glucoside as major compounds [59].…”

“…For instance, the essential oil of P. ruderale at a dose of 100 mg/kg inhibits leukocytes (37%) and mononuclear cell (43%) migration, as well as the accumulation of eosinophils (63%) induced by LPS in mice; in addition, their main monoterpenes limonene and β-myrcene were able to inhibit the migration of the same cells and production of NO, γ-interferon, and IL-4 [38]. Furthermore, Pawłowska et al [30] observed that an aqueous extract of the aerial parts of P. ruderale at a concentration of 50 µg/mL decreased LPS-stimulated IL8 and TNF production by 10% in human neutrophils. Finally, a methanolic extract of Porophyllum tagetoides possesses compounds that help modulate NF-κB activation by decreasing LPS-induced iROS [39].…”

“…Furthermore, P. ruderalle is used in folk medicine in Brazil for leishmaniasis, closing wounds, general pain, and internal bruising [24]. Some pharmacological properties have also been described for this plant, such as antioxidant, antimicrobial, anti-nociceptive, anti-inflammatory and antispasmodic activity [23,[25][26][27][28][29][30]. Due to the diuretic, anti-inflammatory and antioxidant properties of papaloquelite, and the close relationship either these biological activities and the development of kidney disease, this plant could be an important source of compounds for the treatment of KAI.…”

Comparison of Phytochemical Composition and Untargeted Metabolomic Analysis of an Extract from Cnidoscolus aconitifolius (Mill.) I. I. Johnst and Porophyllum ruderale (Jacq.) Cass. and Biological Cytotoxic and Antiproliferative Activity In Vitro

“…The identified phenolics in CA are similar to those previously reported [ 21 , 22 ], but the values for quercetin are lower than those informed (16.9 µg equivalents/g sample) [ 21 , 22 ]. Quercetin, kaempferol, rutin, protocatechuic acid, and glycosilated flavonols are some of the most reported phenolic compounds in ethanolic and methanolic extracts of CA [ 23 ].…”