“…This control involves multiple regulatory mechanisms during transcription (e.g., miRNA control) and translation (e.g., ubiquitin‐proteasome‐dependent degradation; Gsponer et al, ; Babu et al, ; Vacic and Iakoucheva, ; Vacic et al, ). Missense mutations can manifest their impact and possibly cause diseases via disorder‐to‐order transitions [Hu et al, ; Vacic and Iakoucheva, ; Vacic et al, ; Schuch et al, ], since they could affect disorder‐relevant protein functions (protein–protein and protein‐ligand interactions, post‐translational modifications and macromolecular complex assembly). A high percentage of IDPs were associated with many diseases such as cancer (79%, Iakoucheva et al, ), cardiovascular diseases (57%; Cheng et al, ), and neurodegenerative diseases (about 80%, Raychaudhuri et al, ), resulting in the “disorder in disorder” (D 2 ) concept [Uversky et al, ].…”