The contribution of serum hepatitis B virus load in the carcinogenesis and prognosis of hepatocellular carcinoma: evidence from two meta-analyses

Chen, Xueqin; Wu, Fan; Liu, Yanmei; Lou, Jiao; Zhu, Beibei; Zou, Li; Chen, Wei; Gong, Jing; Wang, Ying; Zhong, Rong

doi:10.18632/oncotarget.10335

Cited by 12 publications

(15 citation statements)

References 49 publications

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“…Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of cancer-related mortality worldwide [ 1 , 2 ]. In Asia and sub-Saharan Africa areas, over 5% of the populations suffered chronically infected chronic hepatitis B virus (HBV) infection, which could reflect the elevated prevalence of HCC [ 1 , 3 – 5 ]. In china, the estimated new cases and deaths for HCC were 466.1 and 422.1 thousands, respectively [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

et al. 2017

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Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of cancer-related mortality worldwide. Recent studies identified that circ-ITCH Suppresses mutiple cancers proliferation via inhibiting the Wnt/beta-Catenin pathway. In current study, conducted a genetic association study together with epidemiological follow-up study to delineate the role of circ-ITCH in the development and progression of HCC. we found rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1×10-3) and rs4911154 (adjusted OR =1.27; 95% CI=1.14-1.43; P value =3.7×10-5) were significantly associated with increased HCC risk. The expression level of circ-ITCH was significantly lower in HCC tissues, compared with that in adjacent tissues (P value < 0.001). Cox regression analysis indicated that high expression of circ-ITCH was associated with favorable survival of HCC (HR=0.45; 95% CI=0.29-0.68; P value < 0.001). These results indicate that circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

et al. 2017

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“…These were largely in line with the results of the previous studies . In particular, the Taiwan REVEAL‐HBV study, the Jiangsu Qidong cohort study and a meta‐analysis reported dose‐dependent relationship between HBV DNA and increased liver cancer risk, then a decrease in magnitude of the association in the highest DNA level groups, which is in concordance with our observations. On the other hand, as another major viral cause of liver cancer worldwide especially in western countries, (4) HCV infection showed a very low prevalence in this population, and there is no significant association detected between HCV and liver cancer in this analysis.…”

Section: Discussionmentioning

confidence: 99%

Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population

Liu

Baecker

et al. 2019

Liver International

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Background & Aims:The potential interaction between family history of liver cancer and HBV infection on liver cancer has not been fully examined. Methods: We conducted a population-based case-control study composed of 2011 liver cancer cases and 7933 controls in Jiangsu province, China from 2003 to 2010. Data on major risk or protective factors were collected and HBV/HCV sero-markers were assayed using blood samples. Semi-Bayes (SB) adjustments were applied to provide posterior estimates. Results: Both family history of liver cancer (adjusted odds ratios [OR]: 4.32, 95% confidence intervals [CI]: 3.25-5.73) and hepatitis B surface antigen (HBsAg) positivity R E FE R E N C E S

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“…Androgens stimulate virus replication and transcription in males causing a higher viral load which is associated with an increased risk of occurrence of HCC [13] . In fact, high HBV-DNA serum levels have been reported to be associated with a nonlinear doseresponse to a higher incidence and recurrence of HCC [14] . Furthermore, it has been reported that estrogens appear to act as protectors towards the development of HCC [15] .…”

Section: Hcc and Hbv Chronic Infectionmentioning

confidence: 99%

“…As mentioned above, high viral loads, as well as a seropositive status of HBe antigen (HBeAg) are associated with a higher risk of developing HCC [14] . It has been reported that HBeAg seropositive patients has a relative risk of HCC of 60.2 compared to 9.6 of those seronegative [27] .…”

Section: Hcc and Hbv Chronic Infectionmentioning

confidence: 99%

Mechanisms and clinical behavior of hepatocellular carcinoma in HBV and HCV infection and alcoholic and non-alcoholic fatty liver disease

Nevola¹,

Rinaldi²,

Giordano³

et al. 2018

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Hepatocellular carcinoma (HCC) is the main tumor of the liver and is the sixth most frequently diagnosed tumor in the world. It is the evolution of chronic hepatic injury secondary to different etiologies. Chronic hepatitis B virus and hepatitis C virus infection, chronic alcoholic hepatitis, as well as non-alcoholic fatty liver disease are the most common causes behind the development of HCC. The introduction of effective prophylaxis and treatment against hepatitis B, the recent use of highly effective hepatitis C treatments, as well as lifestyle changes observed in recent decades in the general population causing an increase in obesity and metabolic syndrome have led to significant epidemiological change in HCC in relation to the changed etiologic prevalence of liver injury. Increasing evidence was emerging, emphasizing how the development of HCC is a complex and multifactorial process. The knowledge of the molecular mechanisms involved is important for the understanding of the basic factors of the development of hepatocarcinogenesis and of possible therapeutic approaches. Several pathogenic mechanisms and clinical expression of HCC occur in relation to the different etiologies of the underlying liver disease. The different clinical behavior of HCC often makes diagnosis difficult at an early stage, that is necessary for an effective therapeutic approach. This review analyzes the possible different pathogenic mechanisms involved in the development of HCC and emphasizes the different epidemiological and clinical aspects of HCC observed in the most common forms of liver diseases of viral and non-viral origin.

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The contribution of serum hepatitis B virus load in the carcinogenesis and prognosis of hepatocellular carcinoma: evidence from two meta-analyses

Cited by 12 publications

References 49 publications

Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population

Mechanisms and clinical behavior of hepatocellular carcinoma in HBV and HCV infection and alcoholic and non-alcoholic fatty liver disease

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