The contribution of the immune system to parturition

Jongh, R. De; Jorens, P. G.; Student, I.; Heylen, R.

doi:10.1155/s0962935196000233

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…This has an effect on ripening the cervix, promoting uterine contractions and membrane rupture. 6,7 As with other surgical procedures cesarean section provokes further increases in serum cytokine levels with consequences on host immunomodulation and recovery of the parturient. 8 The perioperative changes of serum TNF-a and IL-6 and the effects of different anesthetic techniques have been investigated in surgical patients.…”

Section: Introductionmentioning

confidence: 99%

A randomized study of maternal serum cytokine levels following cesarean section under general or neuraxial anesthesia

Dermitzaki

Staikou

Petropoulos

et al. 2009

International Journal of Obstetric Anesthesia

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Section: Introductionmentioning

confidence: 99%

A randomized study of maternal serum cytokine levels following cesarean section under general or neuraxial anesthesia

Dermitzaki

Staikou

Petropoulos

et al. 2009

International Journal of Obstetric Anesthesia

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“…interleukin-1␤ (IL-1␤), tumor necrosis factor-␣ (TNF␣), IL-6, and IL-8] and PGs, both basally and in response to inflammatory stimuli and bacterial products (1)(2)(3)(4)(5)(6)(7). Parturition, both at term and preterm, is associated with an increased production of these proinflammatory mediators by gestational tissues, whereas in the setting of intrauterine infection this response is greatly amplified (3,4,8,9).…”

mentioning

confidence: 99%

Labor-Associated Changes in Interleukin-10 Production and Its Regulation by Immunomodulators in Human Choriodecidua

Simpson

Keelan

Mitchell

1998

The Journal of Clinical Endocrinology &Amp; Metabolism

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Parturition is associated with increased production of proinflammatory mediators by gestational tissues. Interleukin-10 (IL-10) is an antiinflammatory cytokine produced by human chorion, decidual, and trophoblast tissues. To study the effects of immunomodulators on IL-10, IL-6, and PGE2 production by human choriodecidua before and after labor, an organ explant system was established. Tissue disks (6 mm) were excised from choriodecidual membranes obtained at term by cesarean section before labor (n=6-7) or after spontaneous vaginal delivery (n=7-8). After 24-h equilibration in medium, the tissues were treated with IL-1beta (10 ng/mL), tumor necrosis factor-alpha (100 ng/mL), lipopolysaccharide (5 microg/mL), dexamethasone (1 micromol/ L), or an appropriate vehicle control (n=3 wells/treatment) for 24 h. Media were harvested, and IL-10, IL-6, and PGE2 concentrations were determined by immunoassay. Basal choriodecidual production rates of IL-10 were significantly decreased with labor (P < 0.001), whereas PGE2 and IL-6 production rates increased. The production of all three substances was increased by IL-1beta, tumor necrosis factor-alpha, and lipopolysaccharide, but inhibited by dexamethasone. In contrast to PGE2 and IL-6, there was significantly increased responsiveness of IL-10 production to inflammatory stimuli after labor, but decreased responsiveness to the inhibitory effects of dexamethasone. These data indicate that IL-10 could play a role in modulating or promoting resolution of the inflammatory processes associated with labor at term and with intrauterine infection-associated preterm labor.

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“…72 Immune cells contribute to initiation of labor. 73 Cells isolated from decidua of patients who delivered via spontaneous vaginal delivery showed an increase in CD16+CD56 low NK cells and CD19+ B cells, and a decrease in CD4+CD25+ Tregs compared to patients delivered via cesarean section. 74 These same CD19+ B cells may also play a role in supporting fetal development, where IL-10 secreting B cells balance inflammatory cytokines like TNF-α.…”

Section: Dm Alters Immune Cell Function Within the Reproductive Tractmentioning

confidence: 88%

Group B streptococcal infection of the genitourinary tract in pregnant and non‐pregnant patients with diabetes mellitus: An immunocompromised host or something more?

Nguyen

Omage

Noble

et al. 2021

American J Rep Immunol

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Group B Streptococcus (GBS), also known as Streptococcus agalactiae is a Gram-positive bacterium commonly encountered as part of the microbiota within the human gastrointestinal tract. A common cause of infections during pregnancy, GBS is responsible for invasive diseases ranging from urinary tract infections to chorioamnionitis and neonatal sepsis. Diabetes mellitus (DM) is a chronic disease resulting from impaired regulation of blood glucose levels. The incidence of DM has steadily increased worldwide to affecting over 450 million people. Poorly controlled DM is associated with multiple health comorbidities including an increased risk for infection. Epidemiologic studies have clearly demonstrated that DM correlates with an increased risk for invasive GBS infections, including skin and soft tissue infections and sepsis in non-pregnant adults. However, the impact of DM on risk for invasive GBS urogenital infections, particularly during the already vulnerable time of pregnancy, is less clear. We review the evolving epidemiology, immunology, and pathophysiology of GBS urogenital infections including rectovaginal colonization during pregnancy, neonatal infections of infants exposed to DM in utero, and urinary tract infections in pregnant and non-pregnant adults in the context of DM and highlight in vitro studies examining why DM might increase risk for GBS urogenital infection.

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The contribution of the immune system to parturition

Cited by 11 publications

References 14 publications

A randomized study of maternal serum cytokine levels following cesarean section under general or neuraxial anesthesia

A randomized study of maternal serum cytokine levels following cesarean section under general or neuraxial anesthesia

Labor-Associated Changes in Interleukin-10 Production and Its Regulation by Immunomodulators in Human Choriodecidua

Group B streptococcal infection of the genitourinary tract in pregnant and non‐pregnant patients with diabetes mellitus: An immunocompromised host or something more?

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